A0A0V0SF02 · A0A0V0SF02_9BILA
- ProteinVoltage-dependent L-type calcium channel subunit alpha
- GeneCACNA1F
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1854 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 341 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 674 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 990 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | high voltage-gated calcium channel activity | |
Molecular Function | metal ion binding | |
Biological Process | calcium ion import across plasma membrane |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent L-type calcium channel subunit alpha
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Enoplea > Dorylaimia > Trichinellida > Trichinellidae > Trichinella
Accessions
- Primary accessionA0A0V0SF02
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 115-133 | Helical | |||
Transmembrane | 153-174 | Helical | |||
Transmembrane | 186-206 | Helical | |||
Transmembrane | 246-265 | Helical | |||
Transmembrane | 327-348 | Helical | |||
Transmembrane | 360-382 | Helical | |||
Transmembrane | 491-507 | Helical | |||
Transmembrane | 527-552 | Helical | |||
Transmembrane | 559-577 | Helical | |||
Transmembrane | 614-634 | Helical | |||
Transmembrane | 655-672 | Helical | |||
Transmembrane | 684-707 | Helical | |||
Transmembrane | 853-871 | Helical | |||
Transmembrane | 906-929 | Helical | |||
Transmembrane | 1017-1044 | Helical | |||
Transmembrane | 1098-1116 | Helical | |||
Transmembrane | 1128-1148 | Helical | |||
Transmembrane | 1160-1178 | Helical | |||
Transmembrane | 1232-1256 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 63-86 | Disordered | |||
Region | 438-458 | Disordered | |||
Compositional bias | 442-458 | Basic and acidic residues | |||
Region | 773-823 | Disordered | |||
Compositional bias | 778-803 | Basic and acidic residues | |||
Domain | 1393-1427 | Voltage-dependent calcium channel alpha-1 subunit IQ | |||
Region | 1502-1560 | Disordered | |||
Compositional bias | 1523-1537 | Polar residues | |||
Compositional bias | 1542-1560 | Basic and acidic residues | |||
Region | 1681-1700 | Disordered | |||
Region | 1721-1746 | Disordered | |||
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,854
- Mass (Da)211,805
- Last updated2016-03-16 v1
- Checksum20B53672A3EE99A9
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0V0SF48 | A0A0V0SF48_9BILA | CACNA1F | 2067 | ||
A0A0V0SEQ8 | A0A0V0SEQ8_9BILA | CACNA1F | 2027 | ||
A0A0V0SEP4 | A0A0V0SEP4_9BILA | CACNA1F | 2063 | ||
A0A0V0SER4 | A0A0V0SER4_9BILA | CACNA1F | 1993 | ||
A0A0V0SF12 | A0A0V0SF12_9BILA | CACNA1F | 2062 | ||
A0A0V0SFK8 | A0A0V0SFK8_9BILA | CACNA1F | 2044 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 442-458 | Basic and acidic residues | |||
Compositional bias | 778-803 | Basic and acidic residues | |||
Compositional bias | 1523-1537 | Polar residues | |||
Compositional bias | 1542-1560 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JYDL01000013 EMBL· GenBank· DDBJ | KRX25282.1 EMBL· GenBank· DDBJ | Genomic DNA |