A0A0V0SEP4 · A0A0V0SEP4_9BILA

  • Protein
    Voltage-dependent L-type calcium channel subunit alpha
  • Gene
    CACNA1F
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Features

Showing features for binding site.

120632004006008001,0001,2001,4001,6001,8002,000
TypeIDPosition(s)Description
Binding site341Ca2+ (UniProtKB | ChEBI)
Binding site674Ca2+ (UniProtKB | ChEBI)
Binding site1067Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionhigh voltage-gated calcium channel activity
Molecular Functionmetal ion binding
Biological Processcalcium ion import across plasma membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent L-type calcium channel subunit alpha

Gene names

    • Name
      CACNA1F
    • ORF names
      T07_11323

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ISS37
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Enoplea > Dorylaimia > Trichinellida > Trichinellidae > Trichinella

Accessions

  • Primary accession
    A0A0V0SEP4

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane115-133Helical
Transmembrane153-174Helical
Transmembrane186-206Helical
Transmembrane246-265Helical
Transmembrane327-348Helical
Transmembrane360-382Helical
Transmembrane491-507Helical
Transmembrane527-552Helical
Transmembrane559-577Helical
Transmembrane614-634Helical
Transmembrane655-672Helical
Transmembrane684-707Helical
Transmembrane852-870Helical
Transmembrane890-911Helical
Transmembrane923-949Helical
Transmembrane984-1003Helical
Transmembrane1094-1121Helical
Transmembrane1175-1193Helical
Transmembrane1205-1225Helical
Transmembrane1245-1264Helical
Transmembrane1271-1290Helical
Transmembrane1336-1356Helical
Transmembrane1422-1446Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region63-86Disordered
Region438-458Disordered
Compositional bias442-458Basic and acidic residues
Region773-823Disordered
Compositional bias778-803Basic and acidic residues
Domain1602-1636Voltage-dependent calcium channel alpha-1 subunit IQ
Region1711-1769Disordered
Compositional bias1732-1746Polar residues
Compositional bias1751-1769Basic and acidic residues
Region1890-1909Disordered
Region1930-1955Disordered

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,063
  • Mass (Da)
    236,038
  • Last updated
    2016-03-16 v1
  • Checksum
    F57B78C71B366FE8
MCYTIFVVVDIYDHARSEANFNDDVNIGKELSGNEAAALLHGDEARASRADLWQQTLQAAVAAQTESSTTTKKRQQQRKMQRNVQQERPERSLLCLGLKNPIRKLFISIVEWKPFEWLILCMICANCIALAVYQPFPAHDSDRKNAVLEQVEYIFIVVFTIECVMKVIAYGFLFHPGAYLRNGWNLLDFLIVVIGLISTALSTLNIHGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILRAMVPLFHIALLVLFVIIIYAIIGLELFCGKLHKTCVDQWTGEHVPDPGPCGESHTSFHCDRSKNLVCTENHTWPGPNDGITNFDNFGLAMLTVFQCISLEGWTDVMYWVNDSVGREWPWIYFITLVILGSFFVLNLVLGVLSGEFSKEREKARARGLFQKFREKQQLEDDLKGYLDWITQAEDIDLVNEEDEEQEAMDREEFGADGEGGEEGGSKEEFQRQSWFSMKIKRLKKLNRRCRRSCRRIVKSQAFYWLVIVLVFLNTMVLTSEHYGQPEWLDHFQEIANLFFVVLFTLEMFLKMYSLGFVNYFVALFNRFDCFVVIGSILEFALTFAGLMKPLGVSVLRSARLLRIFKVTKYWNSLRNLVASLLNSLRSIASLLLLLFLFIVIFALLGMQVFGGKFNTIDPNMNKPRANFDTFVQALLTVFQILTGEDWNAVMYNGIAAFGGVHSIGVIVCIYFIVLFICGNYILLNVFLAIAVDNLADAESLTAAEKEEENKRANEADPDDDMVVKATADEDAVSVEQFHESGEVKLPFNEPTDAEDEHLASGDEDQEREMENQSQFKPTARPHRQSELNLPKKTKPIPDASSLFLFSSTNKVRIFCNKVINHSYFTNSVLVCILVSSAMLAAEDPLQASSFRNEVLNYFDYFFTTVFTIEISLKVLVYGLILHKGSFCRNAFNLLDMLVVGVSLTSFGLKSGAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLEFMFAIIGVQIFKGSFFRCTDRARLTAEECKGTFIEFEGGDVTRPHVRNREWTNYDFNFDNVQNAMVALFVVSTFEGWPDLLHVAMDSSDEGIGPQYNARVSVAIFFITFIVVIAFFMMNIFVGFVIVTFQSEGEREYENCELDKNQRKCIEFALTAKPQRRYIPKNRFQYKIWWFVTSQPFEYAIFIIIILNTLILGMKHYKSSAAFDEALDVLNLFFTTVFALEFICKLFALTFKHHKMTRTFDDVLDTMNLIFTGIFAMEFILKVMAFRCKNYFGDAWNVFDFIIVLGSFIDIIYGKPGSNIISINFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQIFGKIALNSNTEIHRNNNFQTFPSAVLVLFRSATGEAWQLIMLSCANTPTAMCDPESDDRGQPCGNDFAYPFFISFFMLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFVRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNSTLFALVRTNLKIYTEERPFLFLKKSEKVESQSLVSSNIEEANEQLRAVIKRIWKRTPQRLLDEIVPPSGRDDEITVGKFYATYLIQDYFRRFKKRKEVEQKETNMQGNITMSLQAGLRTLHEIGPEIKRAISGNLETDWSKEFEEPQHRRDHSLFGTLVHALQAHYKPFIEGNLTNPAYSNVNGDLKSQEGDDEAEQQHQQHQQEQQQQLMFNKMNDLKSPPVKSDRDKISEFESDESVCNKPERRCNSFFSNIRRRMDSIVSPSILLFDRVLFDSDHDSSEHEMQERVRFVPRGSKPTGLSFEGSRWLPRKLSFRRAPIGSAAVSNIQQGNNKRLQFSNAIILDDSDPDSVLHSENVVDLTESGDDSKPSASPPLELRDDAYYLDGIDYNTWRPAPMGQGVRLRGRGNNGRRKSRSMPLPHHEHQRNYADVLVEKVLADQGLGRYADPNLIRTTQLEIAEAYNMTEAQMHSAARSLMQRSPKYFEHMGGQRPADIKDFNQYSKTALLKPREINSSEEVDISDDMNMFMSVM

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0V0SF48A0A0V0SF48_9BILACACNA1F2067
A0A0V0SEQ8A0A0V0SEQ8_9BILACACNA1F2027
A0A0V0SER4A0A0V0SER4_9BILACACNA1F1993
A0A0V0SF02A0A0V0SF02_9BILACACNA1F1854
A0A0V0SF12A0A0V0SF12_9BILACACNA1F2062
A0A0V0SFK8A0A0V0SFK8_9BILACACNA1F2044

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias442-458Basic and acidic residues
Compositional bias778-803Basic and acidic residues
Compositional bias1732-1746Polar residues
Compositional bias1751-1769Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JYDL01000013
EMBL· GenBank· DDBJ
KRX25279.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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