A0A0U5B4I9 · A0A0U5B4I9_9BACT
- Protein1-deoxy-D-xylulose-5-phosphate synthase
- Genedxs
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids623 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Catalytic activity
- D-glyceraldehyde 3-phosphate + pyruvate + H+ = 1-deoxy-D-xylulose 5-phosphate + CO2
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Mg2+ ion per subunit.
Note: Binds 1 thiamine pyrophosphate per subunit.
Pathway
Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 73 | thiamine diphosphate (UniProtKB | ChEBI) | |||
Binding site | 114-116 | thiamine diphosphate (UniProtKB | ChEBI) | |||
Binding site | 145 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 146-147 | thiamine diphosphate (UniProtKB | ChEBI) | |||
Binding site | 174 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 174 | thiamine diphosphate (UniProtKB | ChEBI) | |||
Binding site | 284 | thiamine diphosphate (UniProtKB | ChEBI) | |||
Binding site | 366 | thiamine diphosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 1-deoxy-D-xylulose-5-phosphate synthase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | thiamine pyrophosphate binding | |
Biological Process | 1-deoxy-D-xylulose 5-phosphate biosynthetic process | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | |
Biological Process | terpenoid biosynthetic process | |
Biological Process | thiamine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-deoxy-D-xylulose-5-phosphate synthase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Thermodesulfobacteriota > Thermodesulfobacteria > Thermodesulfobacteriales > Thermodesulfobacteriaceae > Caldimicrobium
Accessions
- Primary accessionA0A0U5B4I9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 315-479 | Transketolase-like pyrimidine-binding | |||
Sequence similarities
Belongs to the transketolase family. DXPS subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length623
- Mass (Da)68,281
- Last updated2016-03-16 v1
- MD5 ChecksumCEACB73A641891B081326CEAAE967D8D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP014945 EMBL· GenBank· DDBJ | BAU22976.1 EMBL· GenBank· DDBJ | Genomic DNA |