A0A0U5AEU6 · A0A0U5AEU6_9BACT

Function

function

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site200-203CoA (UniProtKB | ChEBI)
Binding site320CoA (UniProtKB | ChEBI)
Binding site396-398ATP (UniProtKB | ChEBI)
Binding site420-425ATP (UniProtKB | ChEBI)
Binding site509ATP (UniProtKB | ChEBI)
Binding site524ATP (UniProtKB | ChEBI)
Binding site532CoA (UniProtKB | ChEBI)
Binding site535ATP (UniProtKB | ChEBI)
Binding site546Mg2+ (UniProtKB | ChEBI)
Binding site548Mg2+ (UniProtKB | ChEBI)
Binding site551Mg2+ (UniProtKB | ChEBI)
Binding site593CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionacetate-CoA ligase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processacetyl-CoA biosynthetic process from acetate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acetyl-coenzyme A synthetase
  • EC number
  • Short names
    AcCoA synthetase
    ; Acs
  • Alternative names
    • Acetate--CoA ligase
    • Acyl-activating enzyme

Gene names

    • Name
      acsA
    • ORF names
      THC_0109

Organism names

  • Taxonomic identifier
  • Strain
    • TF1
  • Taxonomic lineage
    Bacteria > Thermodesulfobacteriota > Thermodesulfobacteria > Thermodesulfobacteriales > Thermodesulfobacteriaceae > Caldimicrobium

Accessions

  • Primary accession
    A0A0U5AEU6

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue618N6-acetyllysine

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain32-88Acetyl-coenzyme A synthetase N-terminal
Domain100-487AMP-dependent synthetase/ligase
Domain540-618AMP-binding enzyme C-terminal

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    660
  • Mass (Da)
    74,657
  • Last updated
    2016-03-16 v1
  • MD5 Checksum
    76B0FE73B3BDECE6C6D732FA519CAB80
MAEIEALLKEERIFYPPQEGKDQAYINSRYQYDQIYDYSLRDPDGFWSERAKELITWFKYWDRTCYWDFHKPEIRFFEGGKLNASYNCLDRHLFNPDVKNKAAIIWQGEPDQDVRVYTYQMLHDEVCRFANILKFLGVKKGDRVAIYMPMMPEAVAAMLACARIGAIHSVVFGGFSAEALKSRILDAGAKLLITADGTYRGGRRINLLHNAETAIADCECVEKYLVINRFGDALTLSDERGILFDDLIKNKDFAKYCPYEEMDAEDILFILYTSGSTGKPKGIFHTTGGYLVYTAHTTQWVFDVRPEDIFWCTADIGWITGHSYIVYGPLALGATVFMYEGVPTYPDPGRWWELVDRYKVTIFYTAPTVIRALMREGEEWPAKYDLSTLRVLGTVGEPINPEAWIWYHKNVGKGRIPIVDTWWQTETGGHLISPLPYAIPQKPGSATLPLPGIEAVILRADGTPADVNEGGHLCIKRAWPGMARGVWGDPERFKEIYFSRFPGYYLTGDGARVDEDGYFWIMGRLDDVINVSGHRIGTMELESAFVAHAAVAEAAVVGMPHDIKGEAIYAYIVLKEGFEPSEDLKKKLVQHIRKEIGPVATPDVIQFVSGLPKTRSGKIMRRILRKVAAGVYDDLGDTSTLADPSVVEEIIQGRKEIFGK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP014945
EMBL· GenBank· DDBJ
BAU22515.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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