A0A0U5ADL6 · A0A0U5ADL6_ADE08

Function

function

Structural component of the virion that acts as a cement protein on the capsid exterior which mediates the interactions between the hexons, including the peripentonal hexons, and reaches all the way to the penton vertices. Two hexon linking proteins IIIa, one from each facet, stabilize the unique edge interface between a pair of facets. As the virus enters the host cell, hexon linking proteins IIIa are shed concomitant with virion acidification in the endosome. During virus assembly, seems to play a role in the serotype specificity of the packaging of viral DNA via its interaction with packaging protein 3.

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for site.

TypeIDPosition(s)Description
Site549-550Cleavage; by viral protease

GO annotations

AspectTerm
Cellular Componenthost cell nucleus
Cellular Componentviral capsid, decoration

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pre-hexon-linking protein IIIa
  • Alternative names
    • Capsid vertex-specific component IIIa
      (CVSC
      )
    • Protein IIIa
    • pIIIa
  • Cleaved into 1 chains

Gene names

    • Name
      L1

Organism names

Accessions

  • Primary accession
    A0A0U5ADL6

Proteomes

Subcellular Location

Virion
Host nucleus
Note: Surrounds the border of each facet on the capsid exterior. Present in around 60 copies per virion.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, propeptide.

TypeIDPosition(s)Description
ChainPRO_50232905671-549Hexon-linking protein IIIa
ChainPRO_50232905661-565Pre-hexon-linking protein IIIa
Modified residue224Phosphoserine; by host
Modified residue273Phosphothreonine; by host
Modified residue446Phosphoserine; by host
Modified residue456Phosphoserine; by host
Modified residue473Phosphotyrosine; by host
Modified residue477Phosphoserine; by host
Modified residue495Phosphoserine; by host
PropeptidePRO_5011800884550-565

Post-translational modification

Cleaved near the C-terminus by the viral protease during virion maturation to form the mature protein.

Keywords

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Interaction

Subunit

Interacts with hexon proteins; this interaction tethers the peripentonal hexons to hexons situated in the facet. Interacts with the penton protein (via N-terminus). Interacts with packaging protein 3; this interaction is required to promote correct genome packaging.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-106Peripentonal hexon-tethering domain
Region137-250Binding to hexon-linking protein
Region429-462Disordered
Compositional bias509-533Basic and acidic residues
Region509-543Disordered

Sequence similarities

Belongs to the adenoviridae hexon-linking protein IIIa family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    565
  • Mass (Da)
    62,909
  • Last updated
    2016-03-16 v1
  • Checksum
    F713DCC7678C27B8
MSQQQAPDPAIRAALQSQPSGLALDDWEAAMQRIMALTTRNPESFRQQPQANRLSAILEAVVPSRTNPTHEKVLAIVNALAENKAIRPDEAGLVYNALLERVGRYNSTNVQSNLDRLVTDVREAVAQRERFKNEGLGSLVALNAFLATQPANVPRGQDDYTNFISALRLMVTEVPQSEVYQSGPDYFFQTSRQGLQTVNLSQAFKNLRGLWGVQAPVGDRSTVSSLLTPNSRLLLLLIAPFTDSGSVNRNSYLGHLLTLYREAIGQAQVDEQTFQEITSVSRALGQNDTDSLRATLNFLLTNRQQKIPAQYALSAEEERILRYVQQSVGLFLMQEGATPSAALDMTARNMEPSMYAANRPFINKLMDYLHRAASMNSDYFTNAILNPHWLPPPGFYTGEYDMPDPNDGFLWDDVDSAVFSPILQKRQEAVRTPASEGAVGRSPFPSLGSLHSLPDSVNSGRVSRPHLLGEDEYLNDSLLRPPRAKNAMANNGIESLVDKLNRWKTYAQDHREPAPAPRRQRHDRQRGLVWDDEDSADDSSVLDLGGSGRVNPFAHLQPRLGRRMF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias509-533Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB897885
EMBL· GenBank· DDBJ
BAU22124.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp