A0A0U3IAN5 · A0A0U3IAN5_ORYME
- ProteinMultidrug resistance-associated protein 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1511 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- 2',3'-cGAMP(in) + ATP + H2O = 2',3'-cGAMP(out) + ADP + phosphate + H+
- leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
- sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | basolateral plasma membrane | |
Molecular Function | ABC-type xenobiotic transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | glutathione transmembrane transporter activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultidrug resistance-associated protein 1
- EC number
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias
Accessions
- Primary accessionA0A0U3IAN5
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 37-56 | Helical | |||
Transmembrane | 76-94 | Helical | |||
Transmembrane | 106-125 | Helical | |||
Transmembrane | 137-156 | Helical | |||
Transmembrane | 176-192 | Helical | |||
Transmembrane | 313-334 | Helical | |||
Transmembrane | 364-385 | Helical | |||
Transmembrane | 437-459 | Helical | |||
Transmembrane | 465-485 | Helical | |||
Transmembrane | 542-570 | Helical | |||
Transmembrane | 582-607 | Helical | |||
Transmembrane | 949-976 | Helical | |||
Transmembrane | 996-1024 | Helical | |||
Transmembrane | 1070-1091 | Helical | |||
Transmembrane | 1097-1114 | Helical | |||
Transmembrane | 1185-1202 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 326-608 | ABC transmembrane type-1 | |||
Domain | 642-866 | ABC transporter | |||
Region | 870-928 | Disordered | |||
Compositional bias | 893-909 | Polar residues | |||
Compositional bias | 910-928 | Basic and acidic residues | |||
Domain | 956-1236 | ABC transmembrane type-1 | |||
Domain | 1273-1507 | ABC transporter | |||
Sequence similarities
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,511
- Mass (Da)168,730
- Last updated2016-03-16 v1
- Checksum04116401DE7351C7
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 893-909 | Polar residues | |||
Compositional bias | 910-928 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KP725025 EMBL· GenBank· DDBJ | ALU63327.1 EMBL· GenBank· DDBJ | mRNA |