A0A0U3ASH7 · A0A0U3ASH7_ORYME

Function

function

Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO3-; selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentchloride channel complex
Cellular Componentcytosol
Cellular Componentearly endosome membrane
Cellular Componentendoplasmic reticulum membrane
Cellular Componentrecycling endosome membrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionintracellularly ATP-gated chloride channel activity
Molecular Functionisomerase activity
Biological Processbicarbonate transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cystic fibrosis transmembrane conductance regulator
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family C member 7
    • Channel conductance-controlling ATPase
    • cAMP-dependent chloride channel

Gene names

    • ORF names
      FQA47_013640

Organism names

  • Taxonomic identifier
  • Strain
    • Bigg-433
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Beloniformes > Adrianichthyidae > Oryziinae > Oryzias

Accessions

  • Primary accession
    A0A0U3ASH7

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein
Early endosome membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Recycling endosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane72-91Helical
Transmembrane121-143Helical
Transmembrane194-216Helical
Transmembrane222-242Helical
Transmembrane304-326Helical
Transmembrane871-896Helical
Transmembrane936-956Helical
Transmembrane1014-1032Helical
Transmembrane1123-1143Helical
Transmembrane1155-1177Helical

Keywords

PTM/Processing

Keywords

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain82-323ABC transmembrane type-1
Domain422-644ABC transporter
Domain951-1171ABC transmembrane type-1
Domain1230-1461ABC transporter
Region1480-1502Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,502
  • Mass (Da)
    169,064
  • Last updated
    2016-03-16 v1
  • Checksum
    652358FAC67E9F00
MQKSPVEDANFLSRFLFWWITPLLRRGLNKKLELADVYKAPSFDLADTLSERLEREWDREVVSSKRPRLLKALARCFFLPFAFFGILLYLGEASKTVQPQLSGRIIASFDPFHAPERRQGYYLALGLGLLLTARFILLQPAIFGLHHLGMQIRIALFSLIYKKTLKLSSKVLDKITTGQLVSLMSAHLNKLDESLGLAHFVWITPLQCMLCAGLVWELIEVNSLWGLVAMILLGIFQAWLSMTMTPPRAKRGAFTSRRLALTSEIMENIHSVKAYGWEEVMETIIKNIRKDEMTLTRKIGSIRYFYSASYFFSAIVVIMAAIVPQALTNGIILRRIFTTASYCIVLRMTLTRQLPGSIQMWYDTLALIEKIEDFLLKEEYRVLDYSLTTVGLELVNVSASWDEGIVKLFEKIQQENKANGHLNGDGGLFFTNLYVTPVLKNISLLLEEGKMLAVAGSTGSGKSSLLMMILGELVPTEGKIRHSGRISYSPQTSWIMPGTIRDNILFGLTYDEYRYNSIIKACQLEEDFASLPEKDKTSLGEGGSTLSGGQRARICLARSVYKDADLYLLDAPFTHLDIATEKEVFDKCVCKLMGSKTRVVVTSKLEHLKRSDKILMLHNGECYFYGTFSELQAQRPDFSSLLLGLEAYDNIVAERRSSILTETLRRVSVDETAGFRGPEALRQSFQHAPPQSHNGVDGYPEKRKQSLILNPIAAARKISFIGNSQQMGTLPPSLMEEGVNELSDRRFSVVPEDDQVEEVLPRSNLYHHGLQHLGGQRRQSVLAFITNAQGQDRRDKMQSSFRKKLSVTPQYDLATELDIYARRLSKDSVFEITEEVDEEDMEQCFADERENVFVTTSWSTYLRYVSVNRTLIYVLIFIAIVFAIEVAGSVIGIFLITDKVWRDGANPNSPNYIDDQPINSSSPPVHLAVIVTPTSAYYIIYIFVAHSDSILALGVFRGLPLVHSLLTVSERLHEQMLSAVLRAPMSVLNSIKTARIMNRFTKDMAIIEDMLPPMLFDLIQLTLLVIGCIFTVSIMRPYIFIAAIPLAVIFVALRKYYLRTGQQLKQLEAEARTPIFSHLVLSLKGLWTIRAFGRQTYFETLFHKALNTHTATWFHYLSALRWFLFRCDVLFVLFFTAAAFIAVGTNQDRPGEIGIIVALAMLILGTFQWAIITSINVDGLMRSVDRVFKFIDLPSEDMPTGKPGGRQGSDLVIDNPHAQIHWPNRGQLDVKGLTVTYTETGHPVLSNISFSVDGGQSVGLLGRTGSGKSTLLSALLRLACTEGEMSIDGVSSSSVSIQTWRKAFGVVPQRIFILTGTFRMNLDPYGRYSDEDLWRVAEEVGLKSVIEQFPDKLDFHLVDGGSVLSNGHKQLICLARSILSRARILLLDEPSAYLDPITLVVLRKTLKQSFSSCTVILSEHKVEPLLECQSFLMVENGALKNYESLQKLMSEVTHLRQAMSPADQHRFPMLHRLNSTKRALPPTTKISSLPEEAEDEVQDTRL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KP725028
EMBL· GenBank· DDBJ
ALU63330.1
EMBL· GenBank· DDBJ
mRNA
WKFB01000647
EMBL· GenBank· DDBJ
KAF6719091.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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