A0A0U2GNZ6 · A0A0U2GNZ6_MERS

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site5998
Active site6000
Active site6099
Active site6176
Active site6181
Binding site6239-6245S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site6663
Active site6678
Active site6718

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell endoplasmic reticulum-Golgi intermediate compartment
Cellular Componenthost cell membrane
Cellular Componenthost cell perinuclear region of cytoplasm
Cellular Componentmembrane
Molecular Function3'-5'-RNA exonuclease activity
Molecular Function5'-3' DNA helicase activity
Molecular FunctionATP binding
Molecular Functioncysteine-type deubiquitinase activity
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionendonuclease activity
Molecular FunctionG-quadruplex RNA binding
Molecular Functionlyase activity
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular FunctionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
Molecular Functionomega peptidase activity
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionsingle-stranded RNA binding
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription
Biological Processinduction by virus of host autophagy
Biological Processproteolysis
Biological Processsymbiont-mediated degradation of host mRNA
Biological Processsymbiont-mediated perturbation of host ubiquitin-like protein modification
Biological Processsymbiont-mediated suppression of host ISG15-protein conjugation
Biological Processsymbiont-mediated suppression of host NF-kappaB cascade
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processviral protein processing
Biological Processviral RNA genome replication
Biological Processviral translational frameshifting
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ORF1ab polyprotein

Gene names

    • Name
      orf1ab

Organism names

  • Taxonomic identifier
  • Strains
    • Camel/Jeddah/Jd85/2015
    • Camel/Jeddah/Jd86/2015
    • Camel/Jeddah/Jd87/2015
    • Camel/Jeddah/Jd90/2015
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae > Orthocoronavirinae > Betacoronavirus > Merbecovirus

Accessions

  • Primary accession
    A0A0U2GNZ6

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane2175-2195Helical
Transmembrane2307-2325Helical
Transmembrane2337-2362Helical
Transmembrane2756-2777Helical
Transmembrane3024-3049Helical
Transmembrane3061-3092Helical
Transmembrane3112-3138Helical
Transmembrane3564-3582Helical
Transmembrane3594-3613Helical
Transmembrane3620-3638Helical
Transmembrane3669-3687Helical
Transmembrane3694-3710Helical
Transmembrane3730-3752Helical
Transmembrane3764-3786Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain25-149CoV Nsp1 globular
Domain165-193BetaCoV Nsp1 C-terminal
Domain195-475CoV Nsp2 N-terminal
Domain481-715CoV Nsp2 middle
Domain717-853CoV Nsp2 C-terminal
Domain857-966Ubiquitin-like
Domain1110-1276Macro
Domain1278-1404Macro
Domain1404-1477DPUP
Domain1482-1537Ubiquitin-like
Domain1552-1823Peptidase C16
Domain1837-1954Nucleic acid-binding
Domain1967-2088G2M
Domain2214-22803Ecto
Region2364-2454Y1
Domain2364-2737CoV Nsp3 Y
Region2368-2381ZF1
Region2414-2424ZF2
Region2455-2737CoV-Y
Region2637-2737Y4
Domain3151-3247Nsp4C
Domain3248-3553Peptidase C30
Domain3846-3928RdRp Nsp7 cofactor
Domain3929-4127RdRp Nsp8 cofactor
Domain4128-4237Nsp9 ssRNA-binding
Domain4238-4377ExoN/MTase coactivator
Domain4383-4639NiRAN
Domain4644-4742Nsp12 Interface
Domain4743-5310Nsp12 RNA-dependent RNA polymerase
Domain4990-5152RdRp catalytic
Domain5311-5394CV ZBD
Domain5567-5923+RNA virus helicase C-terminal
Domain5980-6195ExoN
Domain6204-6432N7-MTase
Region6318-6332GpppA-binding
Domain6433-6493Nsp15 N-terminal oligomerization
Domain6494-6616AV-Nsp11N/CoV-Nsp15M
Domain6633-6772NendoU
Domain6777-7071Nidovirus-type SAM-dependent 2'-O-MTase

Sequence similarities

Belongs to the coronaviruses polyprotein 1ab family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    7,078
  • Mass (Da)
    789,510
  • Last updated
    2016-03-16 v1
  • Checksum
    14436772872D29A4

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT368862
EMBL· GenBank· DDBJ
ALA49758.1
EMBL· GenBank· DDBJ
Genomic RNA
KT368863
EMBL· GenBank· DDBJ
ALA49769.1
EMBL· GenBank· DDBJ
Genomic RNA
KT368864
EMBL· GenBank· DDBJ
ALA49780.1
EMBL· GenBank· DDBJ
Genomic RNA
KT368865
EMBL· GenBank· DDBJ
ALA49791.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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