A0A0U2F1M2 · A0A0U2F1M2_COLMG
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids181 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Pycnogonida > Pantopoda > Colossendeidae > Colossendeis
Accessions
- Primary accessionA0A0U2F1M2
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 18-48 | Helical | |||
Transmembrane | 69-93 | Helical | |||
Transmembrane | 113-136 | Helical | |||
Transmembrane | 148-175 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusFragment
- Length181
- Mass (Da)19,794
- Last updated2016-03-16 v1
- MD5 Checksum6F00D8997354A445EAFFD802247B3B96
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 181 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KT201813 EMBL· GenBank· DDBJ | AKU53138.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201966 EMBL· GenBank· DDBJ | AKU53291.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201967 EMBL· GenBank· DDBJ | AKU53292.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201968 EMBL· GenBank· DDBJ | AKU53293.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201969 EMBL· GenBank· DDBJ | AKU53294.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201970 EMBL· GenBank· DDBJ | AKU53295.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201971 EMBL· GenBank· DDBJ | AKU53296.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201972 EMBL· GenBank· DDBJ | AKU53297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201973 EMBL· GenBank· DDBJ | AKU53298.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201974 EMBL· GenBank· DDBJ | AKU53299.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201975 EMBL· GenBank· DDBJ | AKU53300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201976 EMBL· GenBank· DDBJ | AKU53301.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201977 EMBL· GenBank· DDBJ | AKU53302.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201978 EMBL· GenBank· DDBJ | AKU53303.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201979 EMBL· GenBank· DDBJ | AKU53304.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201980 EMBL· GenBank· DDBJ | AKU53305.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201981 EMBL· GenBank· DDBJ | AKU53306.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201982 EMBL· GenBank· DDBJ | AKU53307.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201983 EMBL· GenBank· DDBJ | AKU53308.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201984 EMBL· GenBank· DDBJ | AKU53309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201985 EMBL· GenBank· DDBJ | AKU53310.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201986 EMBL· GenBank· DDBJ | AKU53311.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201987 EMBL· GenBank· DDBJ | AKU53312.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201988 EMBL· GenBank· DDBJ | AKU53313.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201989 EMBL· GenBank· DDBJ | AKU53314.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201990 EMBL· GenBank· DDBJ | AKU53315.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201991 EMBL· GenBank· DDBJ | AKU53316.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201992 EMBL· GenBank· DDBJ | AKU53317.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201993 EMBL· GenBank· DDBJ | AKU53318.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201994 EMBL· GenBank· DDBJ | AKU53319.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201995 EMBL· GenBank· DDBJ | AKU53320.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201996 EMBL· GenBank· DDBJ | AKU53321.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201997 EMBL· GenBank· DDBJ | AKU53322.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201998 EMBL· GenBank· DDBJ | AKU53323.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT201999 EMBL· GenBank· DDBJ | AKU53324.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202000 EMBL· GenBank· DDBJ | AKU53325.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202001 EMBL· GenBank· DDBJ | AKU53326.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202002 EMBL· GenBank· DDBJ | AKU53327.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202003 EMBL· GenBank· DDBJ | AKU53328.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202004 EMBL· GenBank· DDBJ | AKU53329.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202005 EMBL· GenBank· DDBJ | AKU53330.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202006 EMBL· GenBank· DDBJ | AKU53331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202007 EMBL· GenBank· DDBJ | AKU53332.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202008 EMBL· GenBank· DDBJ | AKU53333.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202009 EMBL· GenBank· DDBJ | AKU53334.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202010 EMBL· GenBank· DDBJ | AKU53335.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202012 EMBL· GenBank· DDBJ | AKU53337.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202013 EMBL· GenBank· DDBJ | AKU53338.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202014 EMBL· GenBank· DDBJ | AKU53339.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202015 EMBL· GenBank· DDBJ | AKU53340.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202017 EMBL· GenBank· DDBJ | AKU53342.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202018 EMBL· GenBank· DDBJ | AKU53343.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202019 EMBL· GenBank· DDBJ | AKU53344.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202020 EMBL· GenBank· DDBJ | AKU53345.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202021 EMBL· GenBank· DDBJ | AKU53346.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202022 EMBL· GenBank· DDBJ | AKU53347.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202023 EMBL· GenBank· DDBJ | AKU53348.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202024 EMBL· GenBank· DDBJ | AKU53349.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202025 EMBL· GenBank· DDBJ | AKU53350.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202026 EMBL· GenBank· DDBJ | AKU53351.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202027 EMBL· GenBank· DDBJ | AKU53352.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202028 EMBL· GenBank· DDBJ | AKU53353.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202029 EMBL· GenBank· DDBJ | AKU53354.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202030 EMBL· GenBank· DDBJ | AKU53355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202031 EMBL· GenBank· DDBJ | AKU53356.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202032 EMBL· GenBank· DDBJ | AKU53357.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202033 EMBL· GenBank· DDBJ | AKU53358.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202035 EMBL· GenBank· DDBJ | AKU53360.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202036 EMBL· GenBank· DDBJ | AKU53361.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202037 EMBL· GenBank· DDBJ | AKU53362.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202038 EMBL· GenBank· DDBJ | AKU53363.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202039 EMBL· GenBank· DDBJ | AKU53364.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202040 EMBL· GenBank· DDBJ | AKU53365.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202041 EMBL· GenBank· DDBJ | AKU53366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202042 EMBL· GenBank· DDBJ | AKU53367.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202043 EMBL· GenBank· DDBJ | AKU53368.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202056 EMBL· GenBank· DDBJ | AKU53381.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202057 EMBL· GenBank· DDBJ | AKU53382.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202058 EMBL· GenBank· DDBJ | AKU53383.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202059 EMBL· GenBank· DDBJ | AKU53384.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202062 EMBL· GenBank· DDBJ | AKU53387.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202063 EMBL· GenBank· DDBJ | AKU53388.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202064 EMBL· GenBank· DDBJ | AKU53389.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202065 EMBL· GenBank· DDBJ | AKU53390.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202066 EMBL· GenBank· DDBJ | AKU53391.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202067 EMBL· GenBank· DDBJ | AKU53392.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202122 EMBL· GenBank· DDBJ | AKU53447.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202123 EMBL· GenBank· DDBJ | AKU53448.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202124 EMBL· GenBank· DDBJ | AKU53449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202125 EMBL· GenBank· DDBJ | AKU53450.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202126 EMBL· GenBank· DDBJ | AKU53451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202129 EMBL· GenBank· DDBJ | AKU53454.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202130 EMBL· GenBank· DDBJ | AKU53455.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202131 EMBL· GenBank· DDBJ | AKU53456.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202132 EMBL· GenBank· DDBJ | AKU53457.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202133 EMBL· GenBank· DDBJ | AKU53458.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202134 EMBL· GenBank· DDBJ | AKU53459.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202135 EMBL· GenBank· DDBJ | AKU53460.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT202136 EMBL· GenBank· DDBJ | AKU53461.1 EMBL· GenBank· DDBJ | Genomic DNA |