A0A0U2F1M2 · A0A0U2F1M2_COLMG

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • 11349
    • 11536
    • 03_132_2
    • 03_132_5
    • 08709_CEA087
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Pycnogonida > Pantopoda > Colossendeidae > Colossendeis

Accessions

  • Primary accession
    A0A0U2F1M2

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-48Helical
Transmembrane69-93Helical
Transmembrane113-136Helical
Transmembrane148-175Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-181Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    181
  • Mass (Da)
    19,794
  • Last updated
    2016-03-16 v1
  • MD5 Checksum
    6F00D8997354A445EAFFD802247B3B96
LIRTELGMPGSLIGNDQIYNVLVTAHAFIMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLMLLLMSSFVDSGVGTGWTLYPPLSSNLSHSGPSVDLSIFSLHLAGVSSILGAINFITTIINMRSKGMKFELIPLFVWSILITVVLLLLSLPVLAGAITMLLTDRNFN

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue181

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT201813
EMBL· GenBank· DDBJ
AKU53138.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201966
EMBL· GenBank· DDBJ
AKU53291.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201967
EMBL· GenBank· DDBJ
AKU53292.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201968
EMBL· GenBank· DDBJ
AKU53293.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201969
EMBL· GenBank· DDBJ
AKU53294.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201970
EMBL· GenBank· DDBJ
AKU53295.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201971
EMBL· GenBank· DDBJ
AKU53296.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201972
EMBL· GenBank· DDBJ
AKU53297.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201973
EMBL· GenBank· DDBJ
AKU53298.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201974
EMBL· GenBank· DDBJ
AKU53299.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201975
EMBL· GenBank· DDBJ
AKU53300.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201976
EMBL· GenBank· DDBJ
AKU53301.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201977
EMBL· GenBank· DDBJ
AKU53302.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201978
EMBL· GenBank· DDBJ
AKU53303.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201979
EMBL· GenBank· DDBJ
AKU53304.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201980
EMBL· GenBank· DDBJ
AKU53305.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201981
EMBL· GenBank· DDBJ
AKU53306.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201982
EMBL· GenBank· DDBJ
AKU53307.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201983
EMBL· GenBank· DDBJ
AKU53308.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201984
EMBL· GenBank· DDBJ
AKU53309.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201985
EMBL· GenBank· DDBJ
AKU53310.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201986
EMBL· GenBank· DDBJ
AKU53311.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201987
EMBL· GenBank· DDBJ
AKU53312.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201988
EMBL· GenBank· DDBJ
AKU53313.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201989
EMBL· GenBank· DDBJ
AKU53314.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201990
EMBL· GenBank· DDBJ
AKU53315.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201991
EMBL· GenBank· DDBJ
AKU53316.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201992
EMBL· GenBank· DDBJ
AKU53317.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201993
EMBL· GenBank· DDBJ
AKU53318.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201994
EMBL· GenBank· DDBJ
AKU53319.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201995
EMBL· GenBank· DDBJ
AKU53320.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201996
EMBL· GenBank· DDBJ
AKU53321.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201997
EMBL· GenBank· DDBJ
AKU53322.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201998
EMBL· GenBank· DDBJ
AKU53323.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201999
EMBL· GenBank· DDBJ
AKU53324.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202000
EMBL· GenBank· DDBJ
AKU53325.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202001
EMBL· GenBank· DDBJ
AKU53326.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202002
EMBL· GenBank· DDBJ
AKU53327.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202003
EMBL· GenBank· DDBJ
AKU53328.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202004
EMBL· GenBank· DDBJ
AKU53329.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202005
EMBL· GenBank· DDBJ
AKU53330.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202006
EMBL· GenBank· DDBJ
AKU53331.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202007
EMBL· GenBank· DDBJ
AKU53332.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202008
EMBL· GenBank· DDBJ
AKU53333.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202009
EMBL· GenBank· DDBJ
AKU53334.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202010
EMBL· GenBank· DDBJ
AKU53335.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202012
EMBL· GenBank· DDBJ
AKU53337.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202013
EMBL· GenBank· DDBJ
AKU53338.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202014
EMBL· GenBank· DDBJ
AKU53339.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202015
EMBL· GenBank· DDBJ
AKU53340.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202017
EMBL· GenBank· DDBJ
AKU53342.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202018
EMBL· GenBank· DDBJ
AKU53343.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202019
EMBL· GenBank· DDBJ
AKU53344.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202020
EMBL· GenBank· DDBJ
AKU53345.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202021
EMBL· GenBank· DDBJ
AKU53346.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202022
EMBL· GenBank· DDBJ
AKU53347.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202023
EMBL· GenBank· DDBJ
AKU53348.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202024
EMBL· GenBank· DDBJ
AKU53349.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202025
EMBL· GenBank· DDBJ
AKU53350.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202026
EMBL· GenBank· DDBJ
AKU53351.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202027
EMBL· GenBank· DDBJ
AKU53352.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202028
EMBL· GenBank· DDBJ
AKU53353.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202029
EMBL· GenBank· DDBJ
AKU53354.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202030
EMBL· GenBank· DDBJ
AKU53355.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202031
EMBL· GenBank· DDBJ
AKU53356.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202032
EMBL· GenBank· DDBJ
AKU53357.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202033
EMBL· GenBank· DDBJ
AKU53358.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202035
EMBL· GenBank· DDBJ
AKU53360.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202036
EMBL· GenBank· DDBJ
AKU53361.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202037
EMBL· GenBank· DDBJ
AKU53362.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202038
EMBL· GenBank· DDBJ
AKU53363.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202039
EMBL· GenBank· DDBJ
AKU53364.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202040
EMBL· GenBank· DDBJ
AKU53365.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202041
EMBL· GenBank· DDBJ
AKU53366.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202042
EMBL· GenBank· DDBJ
AKU53367.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202043
EMBL· GenBank· DDBJ
AKU53368.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202056
EMBL· GenBank· DDBJ
AKU53381.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202057
EMBL· GenBank· DDBJ
AKU53382.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202058
EMBL· GenBank· DDBJ
AKU53383.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202059
EMBL· GenBank· DDBJ
AKU53384.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202062
EMBL· GenBank· DDBJ
AKU53387.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202063
EMBL· GenBank· DDBJ
AKU53388.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202064
EMBL· GenBank· DDBJ
AKU53389.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202065
EMBL· GenBank· DDBJ
AKU53390.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202066
EMBL· GenBank· DDBJ
AKU53391.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202067
EMBL· GenBank· DDBJ
AKU53392.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202122
EMBL· GenBank· DDBJ
AKU53447.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202123
EMBL· GenBank· DDBJ
AKU53448.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202124
EMBL· GenBank· DDBJ
AKU53449.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202125
EMBL· GenBank· DDBJ
AKU53450.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202126
EMBL· GenBank· DDBJ
AKU53451.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202129
EMBL· GenBank· DDBJ
AKU53454.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202130
EMBL· GenBank· DDBJ
AKU53455.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202131
EMBL· GenBank· DDBJ
AKU53456.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202132
EMBL· GenBank· DDBJ
AKU53457.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202133
EMBL· GenBank· DDBJ
AKU53458.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202134
EMBL· GenBank· DDBJ
AKU53459.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202135
EMBL· GenBank· DDBJ
AKU53460.1
EMBL· GenBank· DDBJ
Genomic DNA
KT202136
EMBL· GenBank· DDBJ
AKU53461.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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