A0A0U2F162 · A0A0U2F162_COLMG

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • 11352
    • 11362
    • 11386
    • 11453
    • 11472
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Chelicerata > Pycnogonida > Pantopoda > Colossendeidae > Colossendeis

Accessions

  • Primary accession
    A0A0U2F162

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-48Helical
Transmembrane69-91Helical
Transmembrane111-131Helical
Transmembrane143-160Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-161Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    161
  • Mass (Da)
    17,636
  • Last updated
    2016-03-16 v1
  • Checksum
    E6E7EEA797196662
LIRTELGMPGSLIGNDQIYNVLVTAHAFIMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLMLLLMSSFVDSGVGTGWTLYPPLSANLSHSGPSVDLSIFSLHLAGVSSILGAINFITTIINMRSKGMKFELIPLFVWSILITVVLLL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue161

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT201731
EMBL· GenBank· DDBJ
AKU53056.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201732
EMBL· GenBank· DDBJ
AKU53057.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201733
EMBL· GenBank· DDBJ
AKU53058.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201734
EMBL· GenBank· DDBJ
AKU53059.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201735
EMBL· GenBank· DDBJ
AKU53060.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201736
EMBL· GenBank· DDBJ
AKU53061.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201737
EMBL· GenBank· DDBJ
AKU53062.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201738
EMBL· GenBank· DDBJ
AKU53063.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201739
EMBL· GenBank· DDBJ
AKU53064.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201740
EMBL· GenBank· DDBJ
AKU53065.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201741
EMBL· GenBank· DDBJ
AKU53066.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201742
EMBL· GenBank· DDBJ
AKU53067.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201743
EMBL· GenBank· DDBJ
AKU53068.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201744
EMBL· GenBank· DDBJ
AKU53069.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201745
EMBL· GenBank· DDBJ
AKU53070.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201746
EMBL· GenBank· DDBJ
AKU53071.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201747
EMBL· GenBank· DDBJ
AKU53072.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201748
EMBL· GenBank· DDBJ
AKU53073.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201749
EMBL· GenBank· DDBJ
AKU53074.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201750
EMBL· GenBank· DDBJ
AKU53075.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201751
EMBL· GenBank· DDBJ
AKU53076.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201752
EMBL· GenBank· DDBJ
AKU53077.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201753
EMBL· GenBank· DDBJ
AKU53078.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201754
EMBL· GenBank· DDBJ
AKU53079.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201755
EMBL· GenBank· DDBJ
AKU53080.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201756
EMBL· GenBank· DDBJ
AKU53081.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201757
EMBL· GenBank· DDBJ
AKU53082.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201758
EMBL· GenBank· DDBJ
AKU53083.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201759
EMBL· GenBank· DDBJ
AKU53084.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201760
EMBL· GenBank· DDBJ
AKU53085.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201761
EMBL· GenBank· DDBJ
AKU53086.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201762
EMBL· GenBank· DDBJ
AKU53087.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201763
EMBL· GenBank· DDBJ
AKU53088.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201764
EMBL· GenBank· DDBJ
AKU53089.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201765
EMBL· GenBank· DDBJ
AKU53090.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201766
EMBL· GenBank· DDBJ
AKU53091.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201767
EMBL· GenBank· DDBJ
AKU53092.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201768
EMBL· GenBank· DDBJ
AKU53093.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201769
EMBL· GenBank· DDBJ
AKU53094.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201770
EMBL· GenBank· DDBJ
AKU53095.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201771
EMBL· GenBank· DDBJ
AKU53096.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201772
EMBL· GenBank· DDBJ
AKU53097.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201773
EMBL· GenBank· DDBJ
AKU53098.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201774
EMBL· GenBank· DDBJ
AKU53099.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201775
EMBL· GenBank· DDBJ
AKU53100.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201776
EMBL· GenBank· DDBJ
AKU53101.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201777
EMBL· GenBank· DDBJ
AKU53102.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201778
EMBL· GenBank· DDBJ
AKU53103.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201779
EMBL· GenBank· DDBJ
AKU53104.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201780
EMBL· GenBank· DDBJ
AKU53105.1
EMBL· GenBank· DDBJ
Genomic DNA
KT201781
EMBL· GenBank· DDBJ
AKU53106.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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