A0A0U1WZ73 · A0A0U1WZ73_OCHCU
- ProteinNitric oxide synthase
- GeneNOS2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1149 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions.
Catalytic activity
- 2 L-arginine + 3 NADPH + 4 O2 + H+ = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2OThis reaction proceeds in the forward direction.
2 CHEBI:32682 + 3 CHEBI:57783 + 4 CHEBI:15379 + CHEBI:15378 = 2 CHEBI:57743 + 2 CHEBI:16480 + 3 CHEBI:58349 + 4 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FAD.
Note: Binds 1 FMN.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 197 | Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calmodulin binding | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | FMN binding | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Molecular Function | nitric-oxide synthase activity | |
Biological Process | nitric oxide biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNitric oxide synthase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Ochotonidae > Ochotona
Accessions
- Primary accessionA0A0U1WZ73
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 39-74 | Disordered | |||
Compositional bias | 44-59 | Basic and acidic residues | |||
Domain | 536-674 | Flavodoxin-like | |||
Domain | 727-969 | FAD-binding FR-type | |||
Sequence similarities
Belongs to the NOS family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,149
- Mass (Da)130,195
- Last updated2016-03-16 v1
- ChecksumDE260591293C9E20
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 44-59 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KC707553 EMBL· GenBank· DDBJ | AHG06384.1 EMBL· GenBank· DDBJ | mRNA |