A0A0U1WZ73 · A0A0U1WZ73_OCHCU

Function

function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (UniProtKB | Rhea| CHEBI:59560 )

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN.
heme b (UniProtKB | Rhea| CHEBI:60344 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site197Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Molecular Functioncalmodulin binding
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Molecular Functionnitric-oxide synthase activity
Biological Processnitric oxide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nitric oxide synthase
  • EC number

Gene names

    • Name
      NOS2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Ochotonidae > Ochotona

Accessions

  • Primary accession
    A0A0U1WZ73

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region39-74Disordered
Compositional bias44-59Basic and acidic residues
Domain536-674Flavodoxin-like
Domain727-969FAD-binding FR-type

Sequence similarities

Belongs to the NOS family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,149
  • Mass (Da)
    130,195
  • Last updated
    2016-03-16 v1
  • Checksum
    DE260591293C9E20
MACPWRFLFKTKSQQCNLTEEKDINNNVGKVTYVLSSPVTQDEPKRHGLGKHHDQPPAVAAEKSPDSLGKLDAPPSACPRHLRIRNWGNGMTLQDTLHLKAKEDSTCKSTYCQGAIMSPKGMTRGPRDRPIPAEELLPQAIEFVNQYYGSCKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAQEMFEHICRHLRYSTNHGNIRSAITVFPQRSDGRHDFRIWNTQLIRYAGYQMPDGTIQGDPANAEFTQLCIDLGWKPRFGRFDVLPLVLQANGQDPELFEIPPELVLEVPMEHPKYEWFRELELKWYALPAVANMLLEAGGLEFPACPFNGWYMGTEIGARDFCDAQRYNILEEVGRRMGLETHRLASLWKDRAVTEINVAVLHSFQKQNVTIMDHHSAAESFMKHMQSEYRTRGGCPADWIWLVPPIAGSITPVFHQEMLNYVLSPFYYYQVEAWKTHMWQDERKRPRRRGLKFRVLVRSVLFASVLMRKTMASRIRATILFATETGKSEALARDLGILFSCAFNPKVLCMDEYRLNSLEQEQLLLVVTSTFGNGDSPGNGEKLKRSLFLLKELTNKFRYAVFGLGSSMYPRFCAFAHDVDQKLSHLGASQLTPTGEGDELSGQEDAFRSWAMQTFKAACETFGIRGKDHIHIPKLYTSSVAWEPHHYRLVQGSQPLDLRKALSNLHAKNVFTLRLKSLQNLQSPKSSRATFLVQLSWEDSPGPSYLPGEHLGVCPSNQPALVQGILERVVDSPDPHHTVSLETLDESGSYWVRDKRLPPCSLSQALTYFLDITTPPTQLLLQKLARLATEEAERQRLLTLSQMQPSEYNKWKLTNSLTLLEVLEEFPSLQVSAAFLLSQLPILKPRYYSISSSQDLTPMEVHLTVAVVTYRPRDGQGPLHHGVCSTWLASLKPQDPVPCFVRSAGGFQLPEDPSLPCILIGPGTGIAPFRGFWQQRLYDSANTGLRGGRMILVSGCRHPEEDHLYWEEELEMMQKGVLHDVHTAYSRLPGQPKVYVQDLLRQKLADEVLRVLLEAPGHIYVCGGVGMARDVAHTLKQLVAAKLGLSEEQVEDYFFRLKSQKRYHEDIFGAAFPYEVKKEGAARQPGNTKL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias44-59Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC707553
EMBL· GenBank· DDBJ
AHG06384.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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