A0A0U1MB98 · A0A0U1MB98_TALIS
- Proteintetrahydrofolate synthase
- GeneFPGS
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1790 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H+ + phosphate
(6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)(n) RHEA-COMP:14738 + CHEBI:30616 + CHEBI:29985 = (6S)-5,6,7,8-tetrahydrofolyl-(γ-L-Glu)(n+1) RHEA-COMP:14740 + CHEBI:456216 + CHEBI:15378 + CHEBI:43474
Pathway
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | tetrahydrofolylpolyglutamate synthase activity | |
Biological Process | one-carbon metabolic process |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nametetrahydrofolate synthase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Trichocomaceae > Talaromyces > Talaromyces sect. Islandici
Accessions
- Primary accessionA0A0U1MB98
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-28 | Disordered | ||||
Sequence: MSLYNFRDYGTGDTRKRIRGEHNHTDST | ||||||
Compositional bias | 10-28 | Basic and acidic residues | ||||
Sequence: GTGDTRKRIRGEHNHTDST | ||||||
Compositional bias | 261-279 | Polar residues | ||||
Sequence: SQVRVSASDSQQGPVSSRE | ||||||
Region | 261-337 | Disordered | ||||
Sequence: SQVRVSASDSQQGPVSSREDPQVPPSPCSPTTTGTQQSERIGNNTRVSSPSSVSPQLSPDTMQPAASPGIHNDTDNV | ||||||
Compositional bias | 289-337 | Polar residues | ||||
Sequence: SPTTTGTQQSERIGNNTRVSSPSSVSPQLSPDTMQPAASPGIHNDTDNV | ||||||
Region | 377-414 | Disordered | ||||
Sequence: ESSLQNGARNSTLEPSHFRSGWQVAPSTEPYTNPQLSN | ||||||
Domain | 1519-1689 | JmjC | ||||
Sequence: PSRPDANPLNFLDIENRTGAFYCPAQITQHDIQTRVAHQRQENVGKIGSTWIWKKPSEFFLLSTRHAVSSIHIDNGGQLTWIRVLEGRKIWYFPRSLNMKTLRWLAMAGSQSPEHYRDGWVKVELCAGDILVMPPGCPHAVFTPDDCLAVGGQFWTTAHLGRTLEVLQMQE | ||||||
Region | 1738-1765 | Disordered | ||||
Sequence: DDSSASSQKSHRGRELRSSRKEQSVQQD | ||||||
Compositional bias | 1741-1759 | Basic and acidic residues | ||||
Sequence: SASSQKSHRGRELRSSRKE |
Sequence similarities
Belongs to the folylpolyglutamate synthase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,790
- Mass (Da)201,469
- Last updated2016-02-17 v1
- ChecksumFD79C237E043BFF1
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 10-28 | Basic and acidic residues | ||||
Sequence: GTGDTRKRIRGEHNHTDST | ||||||
Compositional bias | 261-279 | Polar residues | ||||
Sequence: SQVRVSASDSQQGPVSSRE | ||||||
Compositional bias | 289-337 | Polar residues | ||||
Sequence: SPTTTGTQQSERIGNNTRVSSPSSVSPQLSPDTMQPAASPGIHNDTDNV | ||||||
Compositional bias | 1741-1759 | Basic and acidic residues | ||||
Sequence: SASSQKSHRGRELRSSRKE |
Keywords
- Technical term