A0A0T7EWF2 · A0A0T7EWF2_9VIBR
- ProteinGuanosine-inosine kinase
- Genegsk
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids434 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively.
Catalytic activity
- ATP + guanosine = ADP + GMP + H+
Cofactor
Pathway
Purine metabolism; GMP biosynthesis via salvage pathway.
Purine metabolism; IMP biosynthesis via salvage pathway; IMP from inosine: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 40-45 | GMP (UniProtKB | ChEBI) | ||||
Sequence: DQTLVD | ||||||
Binding site | 93-97 | GMP (UniProtKB | ChEBI) | ||||
Sequence: GTIGN | ||||||
Binding site | 198 | GMP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 284-289 | ATP (UniProtKB | ChEBI) | ||||
Sequence: TAGPVG | ||||||
Binding site | 357 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 402 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | guanosine kinase activity | |
Molecular Function | inosine kinase activity | |
Biological Process | GMP salvage | |
Biological Process | IMP salvage | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGuanosine-inosine kinase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio > Vibrio diabolicus subgroup
Accessions
- Primary accessionA0A0T7EWF2
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 77-291 | Carbohydrate kinase PfkB | ||||
Sequence: YQQLKEENLITNEYAGGTIGNTLHNYSVLADDRSTLLGVMSQDIKIGSYGYRYLCNTSSRMDLNYLQGVDGAIGRCFALITEDGERTFAISEGQMNQLHPDSIPEKIFKNASALVLTSYLVRCKEGDPMPEATMKAIEYAKKNDVPVVLTLGTKFVIQDDPKYWQEFIRDNVSVVAMNEDEAEALTGESDPLAASDKTLEWADLVLCTAGPVGLF |
Sequence similarities
Belongs to the carbohydrate kinase PfkB family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length434
- Mass (Da)48,487
- Last updated2016-02-17 v1
- ChecksumD0871DA4C258EF9B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CCKK01000020 EMBL· GenBank· DDBJ | CDU09969.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAPSFE010000003 EMBL· GenBank· DDBJ | MCZ0740909.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP069195 EMBL· GenBank· DDBJ | QRG81841.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VDEN01000143 EMBL· GenBank· DDBJ | TNC03727.1 EMBL· GenBank· DDBJ | Genomic DNA |