A0A0T6UXP3 · A0A0T6UXP3_9PSED

Function

function

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

1943100200300400500600700800900
TypeIDPosition(s)Description
Binding site547ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionaminoacyl-tRNA editing activity
Molecular FunctionATP binding
Molecular Functionvaline-tRNA ligase activity
Biological Processvalyl-tRNA aminoacylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Valine--tRNA ligase
  • EC number
  • Alternative names
    • Valyl-tRNA synthetase
      (ValRS
      )

Gene names

    • Name
      valS
    • ORF names
      AO726_03770

Organism names

  • Taxonomic identifier
  • Strain
    • TTU2014-080ASC
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A0T6UXP3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, motif, coiled coil.

TypeIDPosition(s)Description
Domain14-621Aminoacyl-tRNA synthetase class Ia
Motif40-50'HIGH' region
Motif544-548'KMSKS' region
Domain664-817Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Coiled coil874-936
Domain878-940Valyl-tRNA synthetase tRNA-binding arm

Domain

The C-terminal coiled-coil domain is crucial for aminoacylation activity.
ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    943
  • Mass (Da)
    106,532
  • Last updated
    2016-02-17 v1
  • Checksum
    8987BAE22CB62056
MDKTYQPHAIETALYQNWEANNYFAPQGSGEPYTIMIPPPNVTGSLHMGHGFNNSIMDALIRFRRMQGRNTLWQPGTDHAGIATQMVVERQLAAEGIGRHDLGREKFLEKVWEWKEQSGGTITRQIRRLGSSVDWSRERFTMDEGLSEAVKEAFVRLHNDGLIYRGKRLVNWDTKFHTAISDLEVENHDEKGSLWNLRYPLADGKKTADGKDYLIVATTRPETMLGDSAVAVHPEDERYKALIGSFVELPLVGRRIPIIGDDYCDPEFGTGCVKITPAHDFNDYEVGKRHNLPLINIFDKDAAVLATAQVFKLDGSVNPDVDGSLPAKYAGLDRFEARKQIVADFEAAGLLEKIEDHALKVPKGDRSGTIIEPWLTDQWYVSTKPLAEKAIAVVESGEIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDDAGNVYVGRDEAEVRAKHNLGDANLRQDEDVLDTWFSSGLWTFSTLGWPQQTDFLKTFHPTDVLVTGFDIIFFWVARMIMLSTHLTGQIPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDGIDLESLVAKRTSGMMQPKLAEKIAKQTRAEFPEGIAAYGTDALRFTNLALASTGRDIKFDMGRVEGYRNFCNKIWNAANFVIENTDGQDTGVNGEPVELSSVDHWIISALQRTEADVTRHLDAFRFDMAAQTLYEFIWDEYCAWYLELVKPVLWDENAPIERQRGTRRTLIRVLEVALRLAHPFMPFITEEIWQRIKAQAGVSGDTIMLQPWPVANEERIDAAAEGDIEWVKQLMLGLRQIRGEMKISMAKRIDIILANTNDEDRRRLADNLPLLNKLAKLESVRVLEAGEEAPMSATALVGEMEVLVPMAGLIDKDAELARLDKEITRLEGEVKRVGGKLNNEGFVAKAPAEVLEKERAKLAEAELALGKMVEQRGKIASL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LKKK01000001
EMBL· GenBank· DDBJ
KRW62547.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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