A0A0T6AYQ9 · A0A0T6AYQ9_9SCAR
- ProteinTyrosine-protein kinase-like otk
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids738 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Acts as a calcium-dependent, homophilic cell adhesion molecule that regulates neural recognition during the development of the nervous system. Component of the repulsive Plexin signaling response to regulate motor axon guidance at the embryonic stage. Also component of a receptor complex that is required in the adult visual system to innervate the lamina layer; specific targeting of R1-R6 axons.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | cell adhesion | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | neurogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase-like otk
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Scarabaeiformia > Scarabaeidae > Dynastinae > Oryctes
Accessions
- Primary accessionA0A0T6AYQ9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 342-363 | Helical | ||||
Sequence: AVLITMSVAAAYIILVVGLMVW |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Interacts with plexA; component of a receptor complex that mediates the repulsive signaling in response to Semaphorin ligands.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 43-140 | Ig-like | ||||
Sequence: PVITMHPSSITVDENENSALFCNYESESESYTHVRWKKDGKLLGDHEDGNSNNPHIKIFKQNGTLLIESTKISDRGEYICEVVTIGFEPIVSNMATVS | ||||||
Domain | 149-230 | Ig-like | ||||
Sequence: PPPVNKKLELGTVAKIHCKAQGTPPPIIHWEKLGSGLDGFASHVTDMNGTLHFNGVLIEDKGKYLCTASNSQGVINATVNID | ||||||
Domain | 235-322 | Ig-like | ||||
Sequence: PKFSVQPKNPTEAIEGSSVAIDCVVEGDPKPTIQWDKNSKMNDFDRSRFIVLENGTLFIKEVHKEDENNYGCTAGSSAGLNRKEVRLV | ||||||
Region | 384-443 | Disordered | ||||
Sequence: GDIEHTELKEAANGCGPGPSKVESEDPEATHKEGQKSDGAETTHSQGSSHSKKSKSSFDK | ||||||
Compositional bias | 407-422 | Basic and acidic residues | ||||
Sequence: SEDPEATHKEGQKSDG | ||||||
Domain | 451-735 | Protein kinase | ||||
Sequence: LKEMKLIGRGEFGDVMVARISKSVLSTPTSDKRHSTISSSGPTDEKELPALVKALTQTKDDNSLAEIKREIDIFSKLSHENITKMYGLCREAEPHFMILEYTDWGDLKQFLVATQKGDPPKLSPTQCLTIVQQIARGMDHLSSSRIIHKDLAARNCVVTSKLLTKIGLSRLTREPYSQEYCKHLNQIIPLRWMPYEAVYEDEYSTKSDVYAFGVVIWEIFQQGELPFPKMNDNSFLTKLKEKSLEWKYHKDTPPELQKLQETCLDSHPQNRPTFNTVVTEIEDIL |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length738
- Mass (Da)82,290
- Last updated2016-02-17 v1
- Checksum8E2F64087334AD3E
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: V | ||||||
Compositional bias | 407-422 | Basic and acidic residues | ||||
Sequence: SEDPEATHKEGQKSDG |
Keywords
- Technical term