A0A0T5ZDF1 · A0A0T5ZDF1_9ARCH

Function

function

Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FMNH2 (UniProtKB | Rhea| CHEBI:57618 )

Note: Reduced FMN (FMNH2).

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site48NADP+ (UniProtKB | ChEBI)
Binding site126-128FMN (UniProtKB | ChEBI)
Binding site287FMN (UniProtKB | ChEBI)
Binding site302-306FMN (UniProtKB | ChEBI)
Binding site329FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionchorismate synthase activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Chorismate synthase
  • EC number
  • Short names
    CS
  • Alternative names
    • 5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

    • Name
      aroC
    • ORF names
      XU09_C0008G0343

Organism names

Accessions

  • Primary accession
    A0A0T5ZDF1

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the chorismate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    364
  • Mass (Da)
    39,165
  • Last updated
    2016-02-17 v1
  • Checksum
    48FA476A25E51D02
MPGSSIGQRLVLTSFGESHGKCVGAVLDGCPAGLELEEKDIQKMLDYRRPGQSQVSTQRKEEDKVEIISGVFRGYTTGAPIAMIIWNKDQDSRAYENFTTKMRPGHSDYPALVKYKKFNDYRGGGRFSGRLTATHVLGGAIARKLLKVTLGIDTNAYTLQIGKIKIKNQPTSKMMKSIYANEVRCPDENSAKLMKKAILDAKKNGDSLGGIIESVTTNLPVGLGDPIFSSLESDLAKALYSIPSVKGVEFGSGFAGSESFGSKNNDLYTIKKGKIVTKTNNSGGILGGLSNGMPIVLRVAFKPASSISKKQSTIDIKTKKPTSLKIVGRHDPCVVPRAPPVVDAFVSLVLADHALLSGFIKPVL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LDXL01000008
EMBL· GenBank· DDBJ
KRT60873.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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