A0A0S7EFY5 · A0A0S7EFY5_9TELE

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site242ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentactivin receptor complex
Cellular Componentbicellular tight junction
Cellular Componentcell surface
Cellular Componentmembrane raft
Molecular Functionactivin binding
Molecular Functionactivin receptor activity, type I
Molecular FunctionATP binding
Molecular FunctionSMAD binding
Molecular Functiontransforming growth factor beta receptor activity, type I
Biological Processapoptotic process
Biological Processcell differentiation
Biological Processheart development
Biological Processnervous system development
Biological Processprotein phosphorylation
Biological Processtransforming growth factor beta receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    TGF-beta receptor type-1
  • EC number
  • Alternative names
    • Transforming growth factor-beta receptor type I

Gene names

    • Name
      TGFR1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Cyprinodontiformes > Poeciliidae > Poeciliinae > Poeciliopsis

Accessions

  • Primary accession
    A0A0S7EFY5

Subcellular Location

Cell junction, tight junction
Cell membrane
; Single-pass type I membrane protein
Cell surface
Membrane raft

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical
Transmembrane126-149Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain185-214GS
Domain215-507Protein kinase

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    507
  • Mass (Da)
    56,376
  • Last updated
    2016-02-17 v1
  • Checksum
    2F605A827813D8D6
DGCQSALLATMDAIACLLLVLLFWTRLHDIDALQCYCDRCSANSSCTTDGVCFVAIKKSGSQQISEQRQCIHDSELIPRDRPFVCAPNSRTDTGIFPMCCSSDYCNKDPDFTVFPEEEKPHSLGPVALAAVIACPVCVMCLLLILAFYICHNQRGLGAGGAGALHHRVPNEEDPSMDHPFITVGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIILQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIASRCSVGGIHEDYQLPYYDLVQSDPSVEEMKKVVCEQKLRPNIPNRWQSCEVGWKGLSQNHCCQSEPAPVMGWTSAGTQPHTTTLP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GBYX01477762
EMBL· GenBank· DDBJ
JAO03927.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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