A0A0S7EFY5 · A0A0S7EFY5_9TELE
- ProteinTGF-beta receptor type-1
- GeneTGFR1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids507 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H+
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 242 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | activin receptor complex | |
Cellular Component | bicellular tight junction | |
Cellular Component | cell surface | |
Cellular Component | membrane raft | |
Molecular Function | activin binding | |
Molecular Function | activin receptor activity, type I | |
Molecular Function | ATP binding | |
Molecular Function | SMAD binding | |
Molecular Function | transforming growth factor beta receptor activity, type I | |
Biological Process | apoptotic process | |
Biological Process | cell differentiation | |
Biological Process | heart development | |
Biological Process | nervous system development | |
Biological Process | protein phosphorylation | |
Biological Process | transforming growth factor beta receptor signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTGF-beta receptor type-1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Atherinomorphae > Cyprinodontiformes > Poeciliidae > Poeciliinae > Poeciliopsis
Accessions
- Primary accessionA0A0S7EFY5
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 6-24 | Helical | |||
Transmembrane | 126-149 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 185-214 | GS | |||
Domain | 215-507 | Protein kinase | |||
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length507
- Mass (Da)56,376
- Last updated2016-02-17 v1
- Checksum2F605A827813D8D6
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GBYX01477762 EMBL· GenBank· DDBJ | JAO03927.1 EMBL· GenBank· DDBJ | Transcribed RNA |