A0A0S6XAX9 · FRBF_BLOB1

  • Protein
    C2H2-type zinc-finger transcription factor frbF
  • Gene
    frbF
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

C2H2-type zinc-finger transcription factor; part of the gene cluster that mediates the biosynthesis of the antifungal antibiotic FR901469, an inhibitor of beta-1,3-glucansynthase, exerting antifungal activity against the pathogenes Candida albicans and Aspergillus fumigatus (PubMed:27660098).
FR901469 is a cyclic depsipeptide containing 12 amino acid residues and a fatty acid chain (PubMed:27660098).
Positively regulates the expression of the FR901469 biosynthesis cluster genes frbA, frbB, frbC, frbG, frbH and frbI (PubMed:27660098, PubMed:28341398).
Affects also the expression of some genes involved in other metabolic pathways, including the ergosterol biosynthetic pathway, beta-1,3-glucan catabolic enzymes or chitinases (PubMed:27660098).

Biotechnology

FR901469 inhibits the activity of 1,3-beta-glucan synthase from Candida albicans and Aspergillus fumigatus (PubMed:11099224, PubMed:11099225).
With minimal inhibitory concentrations (MICs) against Candida albicans and Aspergillus fumigatus of 0.63 ug/ml and 0.16 ug/ml, repectively, FR901469 displays greater inhibitory activity than other 1,3-beta-glucan synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin B (PubMed:11099224, PubMed:11099225).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionmetal ion binding
Biological Processregulation of translation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    C2H2-type zinc-finger transcription factor frbF
  • Alternative names
    • FR901469 biosynthesis cluster protein F

Gene names

    • Name
      frbF
    • ORF names
      ANO11243_029900

Organism names

Accessions

  • Primary accession
    A0A0S6XAX9

Proteomes

Subcellular Location

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004545751-361C2H2-type zinc-finger transcription factor frbF

Family & Domains

Features

Showing features for region, compositional bias, zinc finger.

TypeIDPosition(s)Description
Region70-94Disordered
Compositional bias175-209Polar residues
Region175-211Disordered
Zinc finger325-345C2H2-type; degenerate

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    361
  • Mass (Da)
    39,440
  • Last updated
    2016-02-17 v1
  • Checksum
    9DA22F33546C3D81
MHCPQSARKTRQQQQHPLTDRCAYAGSANMPSAVAIPAPLPPSNCEEGIWLSKSVLMSLLFPNQALPAAHQVSSVETPSTSTTSTSTTTSTSRAASEFDANYCNTVRNPYIPPTPEDKFPVTPPPSLDQTAMSSPAACIPHESGPVRPKQTVAFTPGFSNPYPAFIEQSSVSMPVYEPTPHLHTQPQTQSRPSTQTPHQHQQQPYTFATPPYQPYDHIYSPELDLSLLSTDFSLYPQHPQHPQIPPPDLSLWSPSIDAASPLAASSPDPTTLWAPAIPIAPPQPASKQDGPIPRCWDHGCNGRRFSSIGNLVRHIKEQNGPRARFECRRCGQTFTRSTARSMHVKRGRCEGTMRSKGIGGK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias175-209Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DF938583
EMBL· GenBank· DDBJ
GAM84987.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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