A0A0S6XAX9 · FRBF_BLOB1
- ProteinC2H2-type zinc-finger transcription factor frbF
- GenefrbF
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids361 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
C2H2-type zinc-finger transcription factor; part of the gene cluster that mediates the biosynthesis of the antifungal antibiotic FR901469, an inhibitor of beta-1,3-glucansynthase, exerting antifungal activity against the pathogenes Candida albicans and Aspergillus fumigatus (PubMed:27660098).
FR901469 is a cyclic depsipeptide containing 12 amino acid residues and a fatty acid chain (PubMed:27660098).
Positively regulates the expression of the FR901469 biosynthesis cluster genes frbA, frbB, frbC, frbG, frbH and frbI (PubMed:27660098, PubMed:28341398).
Affects also the expression of some genes involved in other metabolic pathways, including the ergosterol biosynthetic pathway, beta-1,3-glucan catabolic enzymes or chitinases (PubMed:27660098).
FR901469 is a cyclic depsipeptide containing 12 amino acid residues and a fatty acid chain (PubMed:27660098).
Positively regulates the expression of the FR901469 biosynthesis cluster genes frbA, frbB, frbC, frbG, frbH and frbI (PubMed:27660098, PubMed:28341398).
Affects also the expression of some genes involved in other metabolic pathways, including the ergosterol biosynthetic pathway, beta-1,3-glucan catabolic enzymes or chitinases (PubMed:27660098).
Biotechnology
FR901469 inhibits the activity of 1,3-beta-glucan synthase from Candida albicans and Aspergillus fumigatus (PubMed:11099224, PubMed:11099225).
With minimal inhibitory concentrations (MICs) against Candida albicans and Aspergillus fumigatus of 0.63 ug/ml and 0.16 ug/ml, repectively, FR901469 displays greater inhibitory activity than other 1,3-beta-glucan synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin B (PubMed:11099224, PubMed:11099225).
With minimal inhibitory concentrations (MICs) against Candida albicans and Aspergillus fumigatus of 0.63 ug/ml and 0.16 ug/ml, repectively, FR901469 displays greater inhibitory activity than other 1,3-beta-glucan synthase inhibitors such as, WF11899A, echinocandin B, aculeacin A, and papulacandin B (PubMed:11099224, PubMed:11099225).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Biological Process | regulation of translation |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameC2H2-type zinc-finger transcription factor frbF
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Fungi
Accessions
- Primary accessionA0A0S6XAX9
Proteomes
Subcellular Location
Phenotypes & Variants
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000454575 | 1-361 | C2H2-type zinc-finger transcription factor frbF | |||
Sequence: MHCPQSARKTRQQQQHPLTDRCAYAGSANMPSAVAIPAPLPPSNCEEGIWLSKSVLMSLLFPNQALPAAHQVSSVETPSTSTTSTSTTTSTSRAASEFDANYCNTVRNPYIPPTPEDKFPVTPPPSLDQTAMSSPAACIPHESGPVRPKQTVAFTPGFSNPYPAFIEQSSVSMPVYEPTPHLHTQPQTQSRPSTQTPHQHQQQPYTFATPPYQPYDHIYSPELDLSLLSTDFSLYPQHPQHPQIPPPDLSLWSPSIDAASPLAASSPDPTTLWAPAIPIAPPQPASKQDGPIPRCWDHGCNGRRFSSIGNLVRHIKEQNGPRARFECRRCGQTFTRSTARSMHVKRGRCEGTMRSKGIGGK |
Structure
Family & Domains
Features
Showing features for region, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 70-94 | Disordered | ||||
Sequence: HQVSSVETPSTSTTSTSTTTSTSRA | ||||||
Compositional bias | 175-209 | Polar residues | ||||
Sequence: VYEPTPHLHTQPQTQSRPSTQTPHQHQQQPYTFAT | ||||||
Region | 175-211 | Disordered | ||||
Sequence: VYEPTPHLHTQPQTQSRPSTQTPHQHQQQPYTFATPP | ||||||
Zinc finger | 325-345 | C2H2-type; degenerate | ||||
Sequence: FECRRCGQTFTRSTARSMHVK |
Sequence similarities
Belongs to the GLI C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length361
- Mass (Da)39,440
- Last updated2016-02-17 v1
- Checksum9DA22F33546C3D81
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 175-209 | Polar residues | ||||
Sequence: VYEPTPHLHTQPQTQSRPSTQTPHQHQQQPYTFAT |
Keywords
- Technical term