A0A0S6UBX4 · A0A0S6UBX4_CLOBO
- ProteinAspartokinase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids400 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.
Catalytic activity
- ATP + L-aspartate = 4-phospho-L-aspartate + ADP
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 7-10 | ATP (UniProtKB | ChEBI) | ||||
Sequence: KYGG | ||||||
Binding site | 47 | substrate | ||||
Sequence: T | ||||||
Binding site | 74 | substrate | ||||
Sequence: E | ||||||
Binding site | 173-174 | ATP (UniProtKB | ChEBI) | ||||
Sequence: TD | ||||||
Binding site | 179 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 184 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | aspartate kinase activity | |
Molecular Function | ATP binding | |
Biological Process | homoserine biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate | |
Biological Process | threonine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAspartokinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium
Accessions
- Primary accessionA0A0S6UBX4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 265-336 | ACT | ||||
Sequence: ITMEDINEDINIVADIFTKLAEKQINVDMISQTAPINSRISLSFTIPKEDLQDGMKIIKGYAPKDKIKIDEN | ||||||
Domain | 342-400 | ACT | ||||
Sequence: IVGIGMKNTSGVAAKMLKIFSDNNIKIKMITTSEIRITCAINVEDKINAINLVAKEFNL |
Sequence similarities
Belongs to the aspartokinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length400
- Mass (Da)43,472
- Last updated2016-02-17 v1
- ChecksumE308C0EF3CD2AE1E