A0A0S6U6H4 · A0A0S6U6H4_CLOBO
- Protein4-hydroxy-tetrahydrodipicolinate synthase
- GenedapA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids292 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Catalytic activity
- L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O
Pathway
Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.
Features
Showing features for site, binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 45 | Part of a proton relay during catalysis | ||||
Sequence: T | ||||||
Binding site | 46 | pyruvate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Site | 108 | Part of a proton relay during catalysis | ||||
Sequence: Y | ||||||
Active site | 134 | Proton donor/acceptor | ||||
Sequence: Y | ||||||
Active site | 162 | Schiff-base intermediate with substrate | ||||
Sequence: K | ||||||
Binding site | 204 | pyruvate (UniProtKB | ChEBI) | ||||
Sequence: I |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4-hydroxy-tetrahydrodipicolinate synthase activity | |
Biological Process | diaminopimelate biosynthetic process | |
Biological Process | lysine biosynthetic process via diaminopimelate |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-tetrahydrodipicolinate synthase
- EC number
- Short namesHTPA synthase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Clostridiaceae > Clostridium
Accessions
- Primary accessionA0A0S6U6H4
Proteomes
Subcellular Location
Interaction
Subunit
Homotetramer; dimer of dimers.
Structure
Sequence
- Sequence statusComplete
- Length292
- Mass (Da)31,683
- Last updated2016-02-17 v1
- Checksum2955CB7B537EE3AD