A0A0S6TZ81 · A0A0S6TZ81_CLOBO

Function

function

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site25-32ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentDNA helicase complex
Molecular Function3'-5' DNA helicase activity
Molecular Function3'-5' exonuclease activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functiondouble-stranded DNA binding
Molecular Functionisomerase activity
Biological Processdouble-strand break repair via homologous recombination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent helicase/nuclease subunit A
  • EC number
  • Alternative names
    • ATP-dependent helicase/nuclease AddA
    • DNA 3'-5' helicase AddA

Gene names

    • Name
      addA
    • ORF names
      CBO05C_0597

Organism names

Accessions

  • Primary accession
    A0A0S6TZ81

Proteomes

Subcellular Location

Interaction

Subunit

Heterodimer of AddA and AddB/RexB.

Family & Domains

Features

Showing features for domain, coiled coil.

TypeIDPosition(s)Description
Domain4-499UvrD-like helicase ATP-binding
Coiled coil295-322
Domain526-853UvrD-like helicase C-terminal

Sequence similarities

Belongs to the helicase family. AddA subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,279
  • Mass (Da)
    150,509
  • Last updated
    2016-02-17 v1
  • Checksum
    274E035CE1A76C14
MSSTKWTDEQRQAIFTKNCNLLVAAGAGAGKTAVLVQRIIEKILDKEEPIDIDKLLVVTFTNAAAAEMRERIGDAISKGLDEEPESKVLRKQLTLLNKSNIMTIHSFCLQVIKNNFHTIEIDPNFRICDETEGILMKQEAMDELFDELYEIENEDFINLVESYASRKDTRLQEVVLELHRFAKSAPLPYDWLLNMAEGFNVGEEFNFEETLWADMIMEDMKVLLHGFKNMLQQSIEVILNSEGIDYYYEPFKMDLNFINNLLQKSSFKEFRNEIIVYDFPKLPVKRNKDADKEVKERVKKLRDKVKKKIVELKNILDSYENEFIRKEFIFLYPSMKALSNLVILFDKKYEAKKRERDLIDFNDIEHLCLSILTDKTDEGHIIPSNIALDYRKKFAEVLIDEYQDSNLVQEVIMSMVSRVKGYWSFSNSQLVFNEEEINFEEPQVGLDIPNRFMVGDVKQSIYRFRQAKPEIFLDKYNQYSEEEGSKYRKIKLFKNFRSREEVINGVNYLFKQIMSKTIGELDYTEKEALTVGASYGEEVKGEPIELCLMDKKYEISEEVLKEYNMDEEEALDNIQLEGRLVAKKIQEVIGNNLEGGLKVFDKKLGEYRRIQYRDIVILMRATSNWAPVFVEELAKEGIPVFADTNSGYFDTTEIKTIISLLQIIDNPLQDIPLLSVLRSPIASFTDDDLIDIRMVNKNIAFYECMEIIYRLYKNERLDSYYSFYIEDEDKINRIVKDMKEELKNKICSFIEKLNLWRKKSIHIDIDEFIWFLYVETGYYGYVGALPAGEQRQANLRILFQRAKQYEKTSYKGLFNFINFINKLKFSSGDMGSAKILGENENVVRIMSIHKSKGLEFPVVILSGTGKNFNMTDLNKNILFHRDLGYGPDYVDIERRIAYPSLVKNIIKNKIRLETLSEEIRILYVALTRAREKLIITGLINNVDKTVENWFNLSEEKNKVPEYAVMSGKTYLDWIGPAVIKHKDAVSFREELKMTSELSNIVDDKSKWKIELWNKKELLKEKVEEDEVEISEKIKETLMNLEESNYKEEIYKRLSFKYKYDNASNIPTKLSVSDVKKQFILDNEENTEELFKKVELRKPMFMEEKKKISPSERGTIIHLFMQHLDLKKVENEDSIKEQINRLIEKEFITYEQSKVINPYKILKFCRSELGKRMINSNNINREMPFSIEISVLEIYKDLDKEIYKDEKLIIQGIIDCYFEEEEGLVLLDYKTDYVNDIEEIKNRYKIQIKYYEEALKRITGKTVKDKYLYLFSIDNYIKIN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DF384213
EMBL· GenBank· DDBJ
GAE00907.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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