A0A0S4TF38 · A0A0S4TF38_CRYHO

  • Protein
    Adenylate kinase isoenzyme 6 homolog
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site17ATP (UniProtKB | ChEBI)
Binding site19ATP (UniProtKB | ChEBI)
Binding site20ATP (UniProtKB | ChEBI)
Binding site21ATP (UniProtKB | ChEBI)
Binding site22ATP (UniProtKB | ChEBI)
Binding site119ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Biological Processphosphorylation
Biological Processribosomal small subunit biogenesis
Biological ProcessrRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase isoenzyme 6 homolog
  • EC number
  • Short names
    AK6
  • Alternative names
    • Dual activity adenylate kinase/ATPase
      (AK/ATPase
      )

Gene names

    • ORF names
      CHUDEA3_3270

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Cryptosporidiidae > Cryptosporidium

Accessions

  • Primary accession
    A0A0S4TF38

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region38-61NMPbind
Region118-128LID

Sequence similarities

Belongs to the adenylate kinase family. AK6 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    179
  • Mass (Da)
    21,025
  • Last updated
    2016-02-17 v1
  • Checksum
    34EE6DC5DF66221A
MLGKGRKPNILIIGTPGTGKTSLSKKLEKKLEGYKRIELSKAIKKHRLYSEWDDKMGASIFDENLVRRYLKNQLDKYNSKNVGIILDFHSVNFIKRKWFDIVFCLNSETHVLFDRLEKRGYSQDKIKENVECEIFKVIRFDATEIFDEEQIIDLQSNDICEQRSNIKFILNKISSIENS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN877949
EMBL· GenBank· DDBJ
CUV05269.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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