A0A0S4KLG5 · A0A0S4KLG5_9BACT

  • Protein
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
  • Gene
    murF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for binding site.

149550100150200250300350400450
TypeIDPosition(s)Description
Binding site138-144ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionUDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Molecular FunctionUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
Biological Processcell division
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
  • EC number
  • Alternative names
    • D-alanyl-D-alanine-adding enzyme

Gene names

    • Name
      murF
    • ORF names
      NITINOP_0300

Organism names

Accessions

  • Primary accession
    A0A0S4KLG5

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain44-89Mur ligase N-terminal catalytic
Domain136-324Mur ligase central
Domain348-473Mur ligase C-terminal

Sequence similarities

Belongs to the MurCDEF family. MurF subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    495
  • Mass (Da)
    53,202
  • Last updated
    2016-02-17 v1
  • Checksum
    5861D7096ABA0788
MKEKSASEGRKIPMPLFTVEELREVISTKVLSGERLGWLKRPVRRVHLDSRSIRLGDLFVAIRGDRFDGHDFVGEAVSRGAMGAIVHDSFDGASLMKKMGRNGRTPLILGVRDPLFAYQQLAAHHRGRFDVPVVAVTGSNGKTTTKEMVAAVLARRWRVLKTEGNLNNRIGVPRTLFRLDGRHEAAVIEMGVDRVGQTTRLCEIARPTIGIVTNVGPDHLEFFGNMEGSAQAKAELLDLLAENGAAVLNADDPYFEYLASRARCRVVSFGLSPKADVWATDIKPDRRNGTVFNLTLPGKIRHTTVRLHVQGEHNVMNALAAAAVGCELGLSGGLIAKGLSRFRPAAMRSQIVVSRGVTIINDCYNANPASMKAAVRLLAQRGSGRTTIAVLGEMLELGADAASMHEEIGAFVAEQGIHRLVACGALGRHVAAGAERGGLDRSRIVLVSDAVRAGEAVKAVAKSGDVVLVKGSRGMKLERAIEALQGVGSETRKAS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN885086
EMBL· GenBank· DDBJ
CUQ65276.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp