A0A0S3F241 · A0A0S3F241_9SPHN

  • Protein
    Orotidine 5'-phosphate decarboxylase
  • Gene
    pyrF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).

Catalytic activity

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.

Features

Showing features for binding site, active site.

122420406080100120140160180200220
TypeIDPosition(s)Description
Binding site10substrate
Binding site32substrate
Binding site59-68substrate
Active site61Proton donor
Binding site115substrate
Binding site175substrate
Binding site184substrate
Binding site204substrate
Binding site205substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionorotidine-5'-phosphate decarboxylase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Orotidine 5'-phosphate decarboxylase
  • EC number
  • Alternative names
    • OMP decarboxylase
      (OMPDCase
      ; OMPdecase
      )

Gene names

    • Name
      pyrF
    • ORF names
      ATN00_16960

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DE-13
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingobium

Accessions

  • Primary accession
    A0A0S3F241

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-220Orotidine 5'-phosphate decarboxylase

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    224
  • Mass (Da)
    23,350
  • Last updated
    2016-02-17 v1
  • Checksum
    643538D27FE52D2B
MSSPIYVAIDTPELEKAQALAGQVRHHVGGLKLGLEFFCANGHHGVHEMMKFGLPIFLDLKLHDIPNTVAKAIQSLHVLEPAILTVHAAGGRAMLENAKAAAGAHTKVVAVTVLTSLDDGDLLDTGVGGRAEDQVARLADLARSAGLDGIVCSGAEVALVRQAWPEGFFVVPGVRPAGGAMGDQKRAVTPREALDRGASILVVGRPISLAENPDTAAREIEATL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP013264
EMBL· GenBank· DDBJ
ALR21738.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp