A0A0S3F241 · A0A0S3F241_9SPHN
- ProteinOrotidine 5'-phosphate decarboxylase
- GenepyrF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids224 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Catalytic activity
- H+ + orotidine 5'-phosphate = CO2 + UMP
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 10 | substrate | ||||
Sequence: D | ||||||
Binding site | 32 | substrate | ||||
Sequence: K | ||||||
Binding site | 59-68 | substrate | ||||
Sequence: DLKLHDIPNT | ||||||
Active site | 61 | Proton donor | ||||
Sequence: K | ||||||
Binding site | 115 | substrate | ||||
Sequence: T | ||||||
Binding site | 175 | substrate | ||||
Sequence: R | ||||||
Binding site | 184 | substrate | ||||
Sequence: Q | ||||||
Binding site | 204 | substrate | ||||
Sequence: G | ||||||
Binding site | 205 | substrate | ||||
Sequence: R |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | orotidine-5'-phosphate decarboxylase activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrotidine 5'-phosphate decarboxylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingobium
Accessions
- Primary accessionA0A0S3F241
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-220 | Orotidine 5'-phosphate decarboxylase | ||||
Sequence: PIYVAIDTPELEKAQALAGQVRHHVGGLKLGLEFFCANGHHGVHEMMKFGLPIFLDLKLHDIPNTVAKAIQSLHVLEPAILTVHAAGGRAMLENAKAAAGAHTKVVAVTVLTSLDDGDLLDTGVGGRAEDQVARLADLARSAGLDGIVCSGAEVALVRQAWPEGFFVVPGVRPAGGAMGDQKRAVTPREALDRGASILVVGRPISLAENPDTAAREI |
Sequence similarities
Belongs to the OMP decarboxylase family. Type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length224
- Mass (Da)23,350
- Last updated2016-02-17 v1
- Checksum643538D27FE52D2B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP013264 EMBL· GenBank· DDBJ | ALR21738.1 EMBL· GenBank· DDBJ | Genomic DNA |