A0A0S3F1W7 · A0A0S3F1W7_9SPHN

  • Protein
    Fumarate hydratase class II
  • Gene
    fumC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site98-100substrate
Binding site129-132substrate; in site B
Binding site139-141substrate
Binding site187substrate
Active site188Proton donor/acceptor
Active site319
Binding site320substrate
Binding site325-327substrate
Site332Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC
    • ORF names
      ATN00_16400

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DE-13
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Sphingomonadales > Sphingomonadaceae > Sphingobium

Accessions

  • Primary accession
    A0A0S3F1W7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-343Fumarate lyase N-terminal
Domain409-461Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    461
  • Mass (Da)
    48,628
  • Last updated
    2016-02-17 v1
  • Checksum
    EBD83A09CF7C3489
MAETRTETDSIGAIEVPAAAYWGAQTQRSIENFPFGDSERMPIGIVHALAIVKQAAARVNRKHGLDAKLADAIEIAAAEVVEGKLDDQFPLVIWQTGSGTQSNMNVNEVIAGRANEILTGTRGGKAPVHPNDHVNMSQSSNDSFPTAMHIAAALAATRALLPALERLEGALLAKAKAWDRIVKIGRTHLQDATPLTLGQEFSGYVAQLRLARTRTMPLVEHGLTKLAQGGTAVGTGLNTPPGFAEDVAAEIAALTGLPFETAPNKFEALASHDTLVDFSGRLNSIAVAVTKIANDIRLLGSGPRSGLGELDLPANEPGSSIMPGKVNPTQCEMLTMVAAQVIGNHQAVTVGGLQGHLELNVFKPLIGAAVLRSIHLLAVGMDSFAERCVEGLEANAKRIAELVDRSLMLVTALAPEIGYDNAAKIAKHAHVEGLTLKQAGLALGLVDEATFDRLVRPENMV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP013264
EMBL· GenBank· DDBJ
ALR21642.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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