A0A0S2Z5R4 · A0A0S2Z5R4_HUMAN
- Proteinmethylcrotonoyl-CoA carboxylase
- GeneMCCC2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids367 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- 3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-methyl-(2E)-glutaconyl-CoA + ADP + H+ + phosphate
Pathway
Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | ligase activity | |
Biological Process | L-leucine catabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namemethylcrotonoyl-CoA carboxylase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A0S2Z5R4
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 397 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 127 | PRIDE | Phosphoserine | ||||
Sequence: S |
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 49-306 | CoA carboxyltransferase N-terminal | ||||
Sequence: MKALVNQLHERVEHIKLGGGEKARALHISRGKLLPRERIDNLIDPGSPFLELSQFAGYQLYDNEEVPGGGIITGIGRVSGVECMIIANDATVKGGAYYPVTVKKQLRAQEIAMQNRLPCIYLVDSGGAYLPRQADVFPDRDHFGRTFYNQAIMSSKNIAQIAVVMGSCTAGGAYVPAMADENIIVRKQGTIFLAGPPLVKAATGEEVSAEDLGGADLHCRKSGVSDHWALDDHHALHLTRKVVRNLNYQKKLDVTIEP | ||||||
Domain | 309-367 | CoA carboxyltransferase C-terminal | ||||
Sequence: EPLFPADELYGIVGANLKRSFDVREVIARIVDGSRFTEFKAFYGDTLVTGIKPLEKHKT |
Sequence similarities
Belongs to the AccD/PCCB family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length367
- Mass (Da)40,152
- Last updated2016-02-17 v1
- Checksum169CE3602BEC054A
Computationally mapped potential isoform sequences
There are 22 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9HCC0 | MCCB_HUMAN | MCCC2 | 563 | ||
D6RDF7 | D6RDF7_HUMAN | MCCC2 | 357 | ||
D6RD67 | D6RD67_HUMAN | MCCC2 | 115 | ||
D6R9R1 | D6R9R1_HUMAN | MCCC2 | 329 | ||
A0A804HHS4 | A0A804HHS4_HUMAN | MCCC2 | 368 | ||
A0A804HJ31 | A0A804HJ31_HUMAN | MCCC2 | 432 | ||
A0A804HIQ3 | A0A804HIQ3_HUMAN | MCCC2 | 58 | ||
A0A804HJ24 | A0A804HJ24_HUMAN | MCCC2 | 515 | ||
A0A804HJ84 | A0A804HJ84_HUMAN | MCCC2 | 560 | ||
A0A804HIH3 | A0A804HIH3_HUMAN | MCCC2 | 363 | ||
A0A0D9SFE9 | A0A0D9SFE9_HUMAN | MCCC2 | 325 | ||
A0A0G2JM88 | A0A0G2JM88_HUMAN | MCCC2 | 208 | ||
A0A804HLJ9 | A0A804HLJ9_HUMAN | MCCC2 | 606 | ||
A0A804HK37 | A0A804HK37_HUMAN | MCCC2 | 491 | ||
A0A804HJW2 | A0A804HJW2_HUMAN | MCCC2 | 321 | ||
A0A804HJW5 | A0A804HJW5_HUMAN | MCCC2 | 342 | ||
A0A804HJC1 | A0A804HJC1_HUMAN | MCCC2 | 269 | ||
A0A804HJL2 | A0A804HJL2_HUMAN | MCCC2 | 285 | ||
A0A804HKE8 | A0A804HKE8_HUMAN | MCCC2 | 533 | ||
A0A804HL02 | A0A804HL02_HUMAN | MCCC2 | 394 | ||
A0A804HKN6 | A0A804HKN6_HUMAN | MCCC2 | 68 | ||
A0A804HKH3 | A0A804HKH3_HUMAN | MCCC2 | 156 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 367 | |||||
Sequence: T |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC138832 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC143336 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KU178742 EMBL· GenBank· DDBJ | ALQ34200.1 EMBL· GenBank· DDBJ | mRNA |