Results delineate an immunosuppressive mechanism of the hepatoma-intrinsic CCRK signalling and highlight an overexpressed kinase target whose inhibition might empower hepatocellular carcinoma immunotherapy
In glioblastoma cells with deregulated high levels of CCRK its depletion restores cilia through ICK and an ICK-related kinase MAK thereby inhibiting glioblastoma cell proliferation.
results suggest for the first time that CCRK is involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2 cyclin E and Rb.
identification of p42 a novel cyclin-dependent kinase-activating kinase (CAK) activity in human cells; p42 is essential for the phosphorylation of Thr-160 and activation of CDK2 and is indispensable for cell growth
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