A0A0S2Z4R4 · A0A0S2Z4R4_HUMAN
- ProteinHepatocyte growth factor-regulated tyrosine kinase substrate
- GeneHGS
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids777 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | early endosome membrane | |
Cellular Component | endosome | |
Cellular Component | lysosome | |
Molecular Function | kinase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylinositol binding | |
Molecular Function | ubiquitin binding |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameHepatocyte growth factor-regulated tyrosine kinase substrate
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A0S2Z4R4
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Early endosome membrane ; Peripheral membrane protein
Disease & Variants
Organism-specific databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-143 | VHS | ||||
Sequence: ATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFP | ||||||
Domain | 160-220 | FYVE-type | ||||
Sequence: WVDAEECHRCRVQFGVMTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLN | ||||||
Compositional bias | 223-252 | Polar residues | ||||
Sequence: AEGKATSTTELPPEYLTSPLSQQSQLPPKR | ||||||
Region | 223-319 | Disordered | ||||
Sequence: AEGKATSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASSAPPASSLYSSPVNSSAPLA | ||||||
Compositional bias | 285-316 | Polar residues | ||||
Sequence: TYTSYPKAEPMPSASSAPPASSLYSSPVNSSA | ||||||
Region | 338-407 | Disordered | ||||
Sequence: KQEEARKSPTPSAPVPLTEPAAQPGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQ | ||||||
Coiled coil | 470-553 | |||||
Sequence: LQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQT | ||||||
Compositional bias | 718-746 | Polar residues | ||||
Sequence: LPSQDASLPPQQPYIAGQQPMYQQMAPSG | ||||||
Region | 718-777 | Disordered | ||||
Sequence: LPSQDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD | ||||||
Compositional bias | 761-777 | Polar residues | ||||
Sequence: AQGPPAQGSEAQLISFD |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length777
- Mass (Da)86,192
- Last updated2016-02-17 v1
- ChecksumDD64167A19DCF030
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 223-252 | Polar residues | ||||
Sequence: AEGKATSTTELPPEYLTSPLSQQSQLPPKR | ||||||
Compositional bias | 285-316 | Polar residues | ||||
Sequence: TYTSYPKAEPMPSASSAPPASSLYSSPVNSSA | ||||||
Compositional bias | 718-746 | Polar residues | ||||
Sequence: LPSQDASLPPQQPYIAGQQPMYQQMAPSG | ||||||
Compositional bias | 761-777 | Polar residues | ||||
Sequence: AQGPPAQGSEAQLISFD | ||||||
Non-terminal residue | 777 | |||||
Sequence: D |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KU178466 EMBL· GenBank· DDBJ | ALQ33924.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471099 EMBL· GenBank· DDBJ | EAW89675.1 EMBL· GenBank· DDBJ | Genomic DNA |