Promyelocytic leukemia zinc finger controls type 2 immune responses in the lungs by regulating lineage commitment and the function of innate and adaptive immune cells.
Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis.
The Role of Promyelocytic Leukemia Zinc Finger (PLZF) and Glial-Derived Neurotrophic Factor Family Receptor Alpha 1 (GFRalpha1) in the Cryopreservation of Spermatogonia Stem Cells.
we summarize all variant translocations their key features their leukemogenic potential as well as recent advances in studies of PLZF-RARalpha-associated APL. Basic pathogenic differences between classical APL and PLZF-RARalpha-associated APL are further discussed
Study demonstrates that miR-4319 is expressed at a low level in colorectal cancer (CRC) tissues which predicts the poor clinical outcome of CRC. MiR-4319 regulates the proliferation cell cycle invasion and migration of CRC cells. Mechanically miR-4319 is found to be transcriptionally regulated by PLZF and acts as a tumour suppressor in CRC by targeting ABTB1.
a latent enhancer within the ZBTB16/PLZF locus itself that became active gained PLZF p300 and Mediator binding and looped to the promoter of the nicotinamide N-methyltransferase (NNMT) gene.
Study found that ANRIL expression in gastric cancer cell lines and tumor tissues was negatively associated with the level of PLZF and with ANRILrecruited polycomb repressive complex 2 which then drove PLZF silencing by collaborating between H3K27me3 and DNA methylation.
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