This study suggested that high a1-antitrypsin (AAT)expression might be a negative prognostic marker for lung adenocarcinoma. AAT promoted lung adenocarcinoma metastasis whose functional target may be fibronectin . Our findings provide new insight into the mechanisms of lung adenocarcinoma metastasis
The current findings suggest that ATA1 contributes to the pathogenesis of ankylosing spondylitis by up-regulating the gene expression in the synovial tissues.
Candidate biomarkers were in situ verified in tissue arrays and relative concentrations were validated in 84 CRC patients and controls. Alpha1 antitrypsin (A1AT) and cathepsin D (CTSD)were further examined due to the possible importance in human cancers.
The results showed that AAT in the amnion may function as a protective shield at inflammatory sites and not as it loses it inhibitory activity in cases with PROM possibly by oxidation suggesting that its imbalance contributes to PROM.
SERPINA1 was shown to be expressed in 85.7% of malignant versus 14.3% of nonmalignant insulinomas by immunohistochemistry; data are consistent to the possibility that SERPINA1 is a marker of malignancy in insulinomas
The effects of heat shock on acute phase protein synthesis can be modified by preincubation with IL-6 whereas addition of this ligand after heat treatment has no effect on the suppressive effect of heat on the APPR.
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