Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T., Richardson A., Sun S., Yang F., Shen Y.A.[...], Vidal M.View abstractCited forNUCLEOTIDE SEQUENCECategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCCell 164:805-817 (2016)Cited in499+
The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse.Tate P., Skarnes W., Bird A.View abstractAnnotationMECP2 is dispensible in stem cells but is essential for embryonic development.CategoriesFunction, Disease & VariantsSourceGeneRif: 4204PubMedEurope PMCNat Genet 12:205-208 (1996)Mapped to32
Methyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis.Chen L., Zhang M., Yang X., Wang Y., Huang T., Li X., Ban Y., Li Q., Yang Q.[...], Wu J.View abstractAnnotationMethyl-CpG-binding 2 K271 lactylation-mediated M2 macrophage polarization inhibits atherosclerosis.SourceGeneRif: 4204PubMedEurope PMCTheranostics 14:4256-4277 (2024)Mapped to30
Methyl-CpG-binding protein 2 regulates CYP27A1-induced myometrial contraction during preterm labor.Peng T., Cui J., Ni Z., Tang Y., Cao X., Li S., Cheng X., Huang J.View abstractAnnotationMethyl-CpG-binding protein 2 regulates CYP27A1-induced myometrial contraction during preterm labor.SourceGeneRif: 4204PubMedEurope PMCMol Hum Reprod 30:gaae016-gaae016 (2024)Mapped to31
MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.Liu Y., Flamier A., Bell G.W., Diao A.J., Whitfield T.W., Wang H.C., Wu Y., Schulte F., Friesen M.[...], Jaenisch R.View abstractAnnotationMECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.SourceGeneRif: 4204PubMedEurope PMCNeuron 112:1943-1958.e10 (2024)Mapped to29
CRL4<sup>DCAF13</sup> E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes.Ren P., Tong X., Li J., Jiang H., Liu S., Li X., Lai M., Yang W., Rong Y.[...], Zhang Y.L.View abstractAnnotationCRL4[DCAF13] E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes.SourceGeneRif: 4204PubMedEurope PMCCell Mol Life Sci 81:165-165 (2024)Mapped to32
[Genetic analysis and prenatal diagnosis for a Chinese pedigree affected with co-morbid Ornithine carbamoyl transferase deficiency and MECP2 duplication syndrome].Zhang Q., Hao S., Hui L., Zheng L., Wang X., Feng X., Liu F., Chen X., Zhou B.[...], Zhang C.View abstractSourceGeneRif: 4204PubMedEurope PMCZhonghua Yi Xue Yi Chuan Xue Za Zhi 41:306-311 (2024)Mapped to30
Genetic analysis of a pedigree with MECP2 duplication syndrome in China.Zeng L., Zhu H., Wang J., Wang Q., Pang Y., Luo Z., Chen A., Qin S., Zhu S.View abstractAnnotationGenetic analysis of a pedigree with MECP2 duplication syndrome in China.SourceGeneRif: 4204PubMedEurope PMCBMC Med Genomics 17:54-54 (2024)Mapped to29
A proteomic approach to investigate the role of the MECP2 gene mutation in Rett syndrome redox regulatory pathways.Pasqui A., Cicaloni V., Tinti L., Guiotto A., Tinti C., Mori A., Bruttini M., Hayek J., Pecorelli A.[...], Valacchi G.View abstractAnnotationA proteomic approach to investigate the role of the MECP2 gene mutation in Rett syndrome redox regulatory pathways.CategoriesExpressionSourceGeneRif: 4204PubMedEurope PMCArch Biochem Biophys 752:109860-109860 (2024)Mapped to29
Analysis of the interplay between MeCP2 and histone H1 during <i>in vitro</i> differentiation of human ReNCell neural progenitor cells.Siqueira E., Kim B.H., Reser L., Chow R., Delaney K., Esteller M., Ross M.M., Shabanowitz J., Hunt D.F.[...], Ausio J.View abstractAnnotationAnalysis of the interplay between MeCP2 and histone H1 during in vitro differentiation of human ReNCell neural progenitor cells.SourceGeneRif: 4204PubMedEurope PMCEpigenetics 18:2276425-2276425 (2023)Mapped to29
Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants.Zlatic S.A., Werner E., Surapaneni V., Lee C.E., Gokhale A., Singleton K., Duong D., Crocker A., Gentile K.[...], Faundez V.View abstractAnnotationSystemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants.CategoriesFunctionSourceGeneRif: 4204PubMedEurope PMCHum Mol Genet 33:12-32 (2023)Mapped to32
Methyl-CpG binding protein 2 expression is associated with symptom severity in patients with PTSD in a sex-dependent manner.Cosentino L., Witt S.H., Dukal H., Zidda F., Siehl S., Flor H., De Filippis B.View abstractAnnotationMethyl-CpG binding protein 2 expression is associated with symptom severity in patients with PTSD in a sex-dependent manner.CategoriesFunctionSourceGeneRif: 4204PubMedEurope PMCTransl Psychiatry 13:249-249 (2023)Mapped to29
Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study.Canton A.P.M., Tinano F.R., Guasti L., Montenegro L.R., Ryan F., Shears D., de Melo M.E., Gomes L.G., Piana M.P.[...], Latronico A.C.View abstractAnnotationRare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study.CategoriesFunctionSourceGeneRif: 4204PubMedEurope PMCLancet Diabetes Endocrinol 11:545-554 (2023)Mapped to29
Circular RNA CircDHRS3 Aggravates IL-1beta-induced ECM Degradation, Apoptosis, and Inflammatory Response via Mediating MECP2 Expression.Ouyang X., Ding Y., Yu L., Xin F., Yang X., Liu X., Tong S.View abstractAnnotationCircular RNA CircDHRS3 Aggravates IL-1beta-induced ECM Degradation Apoptosis and Inflammatory Response via Mediating MECP2 Expression.CategoriesFunctionSourceGeneRif: 4204PubMedEurope PMCInflammation 46:1670-1683 (2023)Mapped to29
Exploring gastrointestinal health in MECP2 duplication syndrome.Pehlivan D., Ak M., Glaze D.G., Suter B., Motil K.J.View abstractAnnotationExploring gastrointestinal health in MECP2 duplication syndrome.CategoriesFunctionSourceGeneRif: 4204PubMedEurope PMCNeurogastroenterol Motil 35:e14601-e14601 (2023)Mapped to29
MECP2 germline mosaicism plays an important part in the inheritance of Rett syndrome: a study of MECP2 germline mosaicism in males.Wen Y., Wang J., Zhang Q., Yang X., Wei L., Bao X.View abstractAnnotationMECP2 germline mosaicism plays an important part in the inheritance of Rett syndrome: a study of MECP2 germline mosaicism in males.CategoriesSequences, Disease & VariantsSourceGeneRif: 4204PubMedEurope PMCBMC Med 21:155-155 (2023)Mapped to29
Inhibiting lncRNA NEAT1 facilitates the sensitization of melanoma cells to cisplatin through modulating the miR-519c-3p-MeCP2 axis.Chen Y., Chang Y., Zhou J., Lv L., Ying H.View abstractAnnotationInhibiting lncRNA NEAT1 facilitates the sensitization of melanoma cells to cisplatin through modulating the miR-519c-3p-MeCP2 axis.CategoriesFunctionSourceGeneRif: 4204PubMedEurope PMCPathol Res Pract 243:154364-154364 (2023)Mapped to29
DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops.Marchena-Cruz E., Camino L.P., Bhandari J., Silva S., Marqueta-Gracia J.J., Amdeen S.A., Guillen-Mendoza C., Garcia-Rubio M.L., Calderon-Montano J.M.[...], Aguilera A.View abstractAnnotationDDX47 MeCP2 and other functionally heterogeneous factors protect cells from harmful R loops.SourceGeneRif: 4204PubMedEurope PMCCell Rep 42:112148-112148 (2023)Mapped to35
Human MECP2 transgenic rats show increased anxiety, severe social deficits, and abnormal prefrontal neural oscillation stability.Li X., Nie Y., Qiu Z., Wang S.View abstractAnnotationHuman MECP2 transgenic rats show increased anxiety severe social deficits and abnormal prefrontal neural oscillation stability.CategoriesFunction, Disease & VariantsSourceGeneRif: 4204PubMedEurope PMCBiochem Biophys Res Commun 648:28-35 (2023)Mapped to29
Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation.Sun J., Osenberg S., Irwin A., Ma L.H., Lee N., Xiang Y., Li F., Wan Y.W., Park I.H.[...], Ballas N.View abstractAnnotationMutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation.CategoriesNames, Function, Disease & VariantsSourceGeneRif: 4204PubMedEurope PMCCell Rep 42:111942-111942 (2023)Mapped to29
The Chromatin Structure at the <i>MECP2</i> Gene and In Silico Prediction of Potential Coding and Non-Coding <i>MECP2</i> Splice Variants.Shevkoplyas D., Vuu Y.M., Davie J.R., Rastegar M.View abstractAnnotationThe Chromatin Structure at the MECP2 Gene and In Silico Prediction of Potential Coding and Non-Coding MECP2 Splice Variants.CategoriesFunction, ExpressionSourceGeneRif: 4204PubMedEurope PMCInt J Mol Sci 23:15643-15643 (2022)Mapped to29
Wide spectrum of neuronal and network phenotypes in human stem cell- derived excitatory neurons with Rett syndrome-associated MECP2 mutations.Mok R.S.F., Zhang W., Sheikh T.I., Pradeepan K., Fernandes I.R., DeJong L.C., Benigno G., Hildebrandt M.R., Mufteev M.[...], Ellis J.View abstractAnnotationWide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations.CategoriesFunction, Disease & VariantsSourceGeneRif: 4204PubMedEurope PMCTransl Psychiatry 12:450-450 (2022)Mapped to29
Mosaicism of common pathogenic MECP2 variants identified in two males with a clinical diagnosis of Rett syndrome.Cooley Coleman J.A., Fee T., Bend R., Louie R., Annese F., Stallworth J., Worthington J., Buchanan C.B., Everman D.B.[...], Spellicy C.J.View abstractAnnotationMosaicism of common pathogenic MECP2 variants identified in two males with a clinical diagnosis of Rett syndrome.CategoriesSequencesSourceGeneRif: 4204PubMedEurope PMCAm J Med Genet A 188:2988-2998 (2022)Mapped to29
MECP2 Dysautonomia Phenotypes in Boys.Courgeon L., Uguen K., Lefranc J., Lesca G., Ropars J.View abstractAnnotationMECP2 Dysautonomia Phenotypes in Boys.CategoriesSequencesSourceGeneRif: 4204PubMedEurope PMCPediatr Neurol 134:31-36 (2022)Mapped to29
MECP2-related pathways are dysregulated in a cortical organoid model of myotonic dystrophy.Morelli K.H., Jin W., Shathe S., Madrigal A.A., Jones K.L., Schwartz J.L., Bridges T., Mueller J.R., Shankar A.[...], Yeo G.W.View abstractAnnotationMECP2-related pathways are dysregulated in a cortical organoid model of myotonic dystrophy.CategoriesFunctionSourceGeneRif: 4204PubMedEurope PMCSci Transl Med 14:eabn2375-eabn2375 (2022)Mapped to29