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A0A0S2Z3S6 · A0A0S2Z3S6_HUMAN

  • Protein
    Cytochrome b-245 heavy chain
  • Gene
    CYBB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdendrite
Cellular Componentmonoatomic ion channel complex
Cellular ComponentNADPH oxidase complex
Cellular Componentneuronal cell body
Cellular Componentnuclear envelope
Cellular Componentperinuclear endoplasmic reticulum
Cellular Componentphagocytic vesicle
Molecular Functionsuperoxide-generating NAD(P)H oxidase activity
Biological Processcellular response to cadmium ion
Biological Processcellular response to ethanol
Biological Processcellular response to L-glutamine
Biological Processhydrogen peroxide biosynthetic process
Biological Processhypoxia-inducible factor-1alpha signaling pathway
Biological Processinflammatory response
Biological Processinnate immune response
Biological Processmonoatomic ion transmembrane transport
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of tumor necrosis factor production
Biological Processresponse to aldosterone
Biological Processresponse to angiotensin
Biological Processresponse to nutrient
Biological Processresponse to xenobiotic stimulus
Biological Processsuperoxide metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b-245 heavy chain
  • Alternative names
    • CGD91-phox
    • Cytochrome b(558) subunit beta
    • Heme-binding membrane glycoprotein gp91phox
    • Neutrophil cytochrome b 91 kDa polypeptide
    • gp91-1

Gene names

    • Name
      CYBB

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A0S2Z3S6

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical
Transmembrane103-121Helical
Transmembrane167-192Helical
Transmembrane204-221Helical

Keywords

  • Cellular component

Disease & Variants

Organism-specific databases

PTM/Processing

Keywords

Expression

Gene expression databases

Interaction

Subunit

Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1. Interacts with calprotectin (S100A8/9). Interacts with NRROS; the interaction is direct and impairs formation of a stable NADPH oxidase complex. Interacts with CYBC1; CYBC1 may act as a chaperone stabilizing Cytochrome b-245 heterodimer. Interacts with NCF2; the interaction is enhanced in the presence of GBP7. The CYBA-CYBB complex interacts with GBP7.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain287-397FAD-binding FR-type

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    570
  • Mass (Da)
    65,336
  • Last updated
    2016-02-17 v1
  • MD5 Checksum
    D036CB5F9E69AAE333FDA62CE035A092
MGNWAVNEGLSIFVILVWLGLNVFLFVWYYRVYDIPPKFFYTRKLLGSALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHSAIHTIAHLFNVEWCVNARVNNSDPYSVALSELGDRQNESYLNFARKRIKNPEGGLYLAVTLLAGITGVVITLCLILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTAESLAVHNITVCEQKISEWGKIKECPIPQFAGNPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQMKKKGFKMEVGQYIFVKCPKVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWTEGLFNACGCDKQEFQDAWKLPKIAVDGPFGTASEDVFSYEVVMLVGAGIGVTPFASILKSVWYKYCNNATNLKLKKIYFYWLCRDTHAFEWFADLLQLLESQMQERNNAGFLSYNIYLTGWDESQANHFAVHHDEEKDVITGLKQKTLYGRPNWDNEFKTIASQHPNTRIGVFLCGPEALAETLSKQSISNSESGPRGVHFIFNKENF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue570

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU178009
EMBL· GenBank· DDBJ
ALQ33467.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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