A0A0S2PM82 · TCS3_CAMSI
- ProteinCaffeine synthase 3
- GeneTCS1E
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids368 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Involved in the biosynthesis of caffeine (PubMed:26773541).
Catalyzes the conversion of 7-methylxanthine (7mX) to theobromine and of theobromine to caffeine (PubMed:26773541).
Catalyzes the conversion of 7-methylxanthine (7mX) to theobromine and of theobromine to caffeine (PubMed:26773541).
Catalytic activity
- S-adenosyl-L-methionine + theobromine = caffeine + H+ + S-adenosyl-L-homocysteineThis reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Alkaloid biosynthesis.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 23 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 23 | substrate | ||||
Sequence: Y | ||||||
Binding site | 26-30 | substrate | ||||
Sequence: NSSFT | ||||||
Binding site | 64 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 64-65 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: GC | ||||||
Binding site | 65 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 70 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 100-103 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: LNDL | ||||||
Binding site | 137-139 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: SFH | ||||||
Site | 152 | Involved in substrate discrimination | ||||
Sequence: H | ||||||
Binding site | 154-156 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: SYS | ||||||
Binding site | 155-159 | substrate | ||||
Sequence: YSVHW | ||||||
Binding site | 176 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Site | 224 | Involved in substrate discrimination | ||||
Sequence: R | ||||||
Binding site | 262 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 264 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 265 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Site | 268 | Involved in substrate discrimination | ||||
Sequence: C | ||||||
Site | 316 | Involved in substrate discrimination | ||||
Sequence: V | ||||||
Site | 331 | Involved in substrate discrimination | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | paraxanthine:S-adenosyl-L-methionine 3-N-methyltransferase activity | |
Molecular Function | S-adenosylmethionine-dependent methyltransferase activity | |
Molecular Function | theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity | |
Biological Process | methylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCaffeine synthase 3
- EC number
- Short namesTCS1e
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > Ericales > Theaceae > Camellia
Accessions
- Primary accessionA0A0S2PM82
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000451796 | 1-368 | Caffeine synthase 3 | |||
Sequence: MELAMGKVNEVLFMNRGEGESSYAQNSSFTQQVASMARPALENAVKTLFSKDFHLQALNAADLGCAAGPNTFAVISTTKRMMEKKCRELNCQTLELQVYLNDLFGNDFNTLFKGLSSEVVGNKCEEVPCYVMGVPGSFHGRLFPRSSLHLVHSSYSVHWLTQAPKGLTSREGLALNKGKIYISKTSPPVVREAYLSQFHEDFTMFLNARSQEVVPNGCMVLILRGRKASDPSDMESCFTWELLAIAIAELVSQGLIDEDKLDTFNIPCYFPSLEEVKDIVERDGSFTIDHMEGFELDSLQMQENDKWVRGENFTKVVRAFTEPIISNQFGHEIMGKLYDKFTHIVVSDLEAKLPKTTSIILVLSKIDG |
Structure
Family & Domains
Sequence similarities
Belongs to the methyltransferase superfamily. Type-7 methyltransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length368
- Mass (Da)41,183
- Last updated2016-02-17 v1
- ChecksumFB6D135036758AE1