A0A0S2I5P3 · A0A0S2I5P3_ETRSU

Function

function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site129Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Molecular Functionaromatase activity
Molecular Functionheme binding
Molecular Functioniron ion binding
Biological Processfemale gonad development
Biological Processresponse to estradiol

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    aromatase
  • EC number
  • Alternative names
    • Cytochrome P-450AROM
    • Estrogen synthase

Gene names

    • Name
      cyp19a

Organism names

Accessions

  • Primary accession
    A0A0S2I5P3

Subcellular Location

Membrane
; Peripheral membrane protein

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_500659954023-147aromatase

Family & Domains

Sequence similarities

Belongs to the cytochrome P450 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    147
  • Mass (Da)
    17,026
  • Last updated
    2016-02-17 v1
  • Checksum
    7B8208E18F9F91CF
DTLSISLFFMLLLLKQNPPVELQLLQEIDTVVGERQLQNGDLHKLQVLESFINECLRFHPVVDFTMRRALSDDVIEGYRVPKGTNIILNTGRMHRTEFFFKANEFNLENFEKNVPRRYFQPFGSGPRACVGKHIAMVMMKSILVTLL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue147

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT031397
EMBL· GenBank· DDBJ
ALO17604.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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