A0A0S2I5P3 · A0A0S2I5P3_ETRSU
- Proteinaromatase
- Genecyp19a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids147 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Catalytic activity
- testosterone + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 17beta-estradiol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H+
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 129 | Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | membrane | |
Molecular Function | aromatase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Biological Process | female gonad development | |
Biological Process | response to estradiol |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namearomatase
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Cichlomorphae > Cichliformes > Cichlidae > Etroplinae > Etroplus
Accessions
- Primary accessionA0A0S2I5P3
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Peripheral membrane protein
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-22 | ||||
Chain | PRO_5006599540 | 23-147 | aromatase | ||
Structure
Sequence
- Sequence statusFragment
- Length147
- Mass (Da)17,026
- Last updated2016-02-17 v1
- Checksum7B8208E18F9F91CF
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 147 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KT031397 EMBL· GenBank· DDBJ | ALO17604.1 EMBL· GenBank· DDBJ | mRNA |