A0A0S2A4A7 · A0A0S2A4A7_9VIRU

Function

function

Encodes for at least two polypeptides: protease (PR) and reverse transcriptase (RT). The protease processes the polyprotein in cis. Reverse transcriptase is multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA (pgRNA) are encapsidated, and reverse-transcribed inside the nucleocapsid. Partial +DNA is synthesized from the -DNA template and generates the relaxed circular DNA (RC-DNA) genome. After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionaspartic-type endopeptidase activity
Molecular Functionendonuclease activity
Molecular Functionnucleic acid binding
Molecular FunctionRNA-directed DNA polymerase activity
Molecular Functionzinc ion binding
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA-directed DNA polymerase
  • EC number

Organism names

  • Taxonomic identifier
  • Strain
    • WA
  • Taxonomic lineage
    Viruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Caulimoviridae > Vaccinivirus

Accessions

  • Primary accession
    A0A0S2A4A7

Proteomes

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias626-656Polar residues
Region626-660Disordered
Region948-994Disordered
Compositional bias970-985Basic and acidic residues
Domain997-1012CCHC-type
Region1038-1069Disordered
Region1559-1623Disordered
Compositional bias1604-1623Basic and acidic residues
Domain1726-1905Reverse transcriptase

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,597
  • Mass (Da)
    301,680
  • Last updated
    2016-02-17 v1
  • Checksum
    A5051363A24DF6C0
MSGFKLSSPSDEDLNRWLTDELDRVQNKIIGKVKDVDPDHVAMAEPGENHLRNGKVLIHQMNRMFATINTMFEKQLWFEQRQKVLFQNLWDFLNSYDENQKAQQKALKDSQDNIALATRNIARMLEQVKGIEEVINTVFQTIEGILNVNKQFMTAEKQREQILQSQLKQIKDQLAEPVVLSKPVSDPALEGHLKSINRGVKNLVERAELLIDYEELAAKIGKNISTQGIAVSERSKSFMSFDHPKPVESVLPKARMFSMFAGGKPKSSIVRSLELEVEEQPKVLKDYKVPKLSVKQLYEQGSMMQRNAYRIKQIERKIPYDPNTKVIHLVDKGEMDRMKAKGYEYVHFGAVQVVFRLLARRDLNCSVLSICRDNRLKSLQKGLLGALQASLNNQVAYFVCIPNFSCTIEDAHEALVLCVQTHGTDFKEGYTDLAIEYIVTYKFMTSDMEAMSKLKATEGFNSMVISDRNNHTISHTKKIDWKELNQSEFPKEWSINSEEPPEAKSSSVITGIYQHENGNISMRFHQAGEGSSHSKAQTHPVHIFDDEPIQLDVSKSGRPKARMIRASTRKEVVVELHDINSIREISDEKLDEIYATTSDPQYFNYTVLPEMQRRINQGISVRAISQSVNRPSTSGDSKEVPITSEVPSSSTLEGKGKTKKFTPAGSSIKLPLITGVPTGKPNEFNTERYKPRIEPNPAVSPNGVWLDIDNNPDPRGNIDEWVNTMNMLIVSETGKAWSPDEARTYYACTFKGIARKWFDKYKETDEYVLWLSTIERSKSPSDFATCLYKQFCREQDPSKKEKDLEILKGKLVNLTISDLKYFLSYVNEYNLAYYNLGIFNNNTYRDMFIQKLPDPWKEYLTNERAKEAGNEEWTLGNLIEFVKTKLADLAIQAWRAKRMQKLYSKSGLSFCQHLIDIPTQWGGRNKELKHKKKGKKIKSFKRYKFRKSKKKGFEKSKINPQKNFKRRFKQKSGKEIEDRKKQSKSKPTSSKGVANVCWNCNQQGHFSRECPRKNARLIELQEAADTWEIPLMRIEEDDDYSDTSSIYSLETESDSESSDSDQESEDEDTVRMIKTQFGIKTIRLNNWPHDTQEIGDVVSFEAILEYEKFECDFCKTSADQYTPVIQRSDLSKEGTISYHTWCFTSLVMRETKNAEVPQLVQREVDLAKLRDAKKKFEQAQLKEEQERLRATRRPVILEVYDDAEELEEMSKIGGHLEELSIKLRRPVAASPGATSSNPLEENVDTPKDLKGQILLCPIFKGPIPKRTEADWKREEEERNRKLVESYRKLKLFERYKEVRNEVLQQIPQHQIPINTIITVKSSPTEMLADIEKLMEEVKKLQQKESTPEDKPDATPEFRHKDNSIYISAAFRFKGYEEYHLHCLVDTGASITLATQWAIPEEKWITIPHGNEIKITVANGETCKIDKYATNVPIYISGIKFTIEKVLQFNKQGCDFLIGNDFFMKYAPYTQYPDRISIAKNGISYITNVVERPVSVAYRKEFLERRKIPDHQQSHKVKCGENYKVQKQAQENDFTIEDYGTTDSEAEEPIYDAIYDKGFQPIESDDEPNDEIQPINDEPNEEVRPGFQPIESNDEPNNEIQPSNDEPNKEVRPKPTKDIRPKPITEEDFQAELRLVEAHYEKQARPKQRPNLNVLEEQISRCSIEELTKQLEPNISDNPIHKWDVTQTYADIQLKDPYALIRVKPMPYSAEDEAEFERQLEEQLKLELIQPSKSPHSSPAFCVRNHAEIKRQKARIVINYKELNRVTKDDGYFLPNLETLVYQVAEARVFSKFDCKSGYWQIKLTPESIPLTAFSTPKGQYEWKVLPFGLKNAPNIFQRRMDKIFKDCYQFCGVYVDDILVFSKDKEEHLLHLDIIINKIVQNGIIIGRTKYELVRESIDFLGVTICKGKIKLQPHILTHLMEFPDKLKDRLQVQQFLGCVNYAGKFIQRLAELCSVLHTKLKKDHKWKFTEDDVKRVQLIKKVCANLPELTLPPPTWKIVLQTDASDHHWAGTIGAISPDKKEEVICAYRSGTFKPAEQNYSTQEKEVLAIIRTIQKAKIFVLKPFLVRTDSKFAALFLDKKINESLARGRLIRWQIMLRQYYLDIEHIPGVSNYLPNALTREMAGCNIIYQIKMVNHGKAPRMDLRDVITSKARARENQQLENEDIHWKQHLASTSRSFAKRKDVPMPSPIPPPFEYKTYRRLTEEQKSQLDWLTSSWHTVDQDTFFDVLKAMAKEFEGLNKLKNGNPAKRVKTSREAKLARWKAQPKKFTFFEEWRTILLRRLRNWTNGATIMDEELYQRIINTPCRAQLQWWSQLNKLWQYQPPEQSFICKATCFDNNHTMLKLKCPPINKLTPEFMDWFENGFIQSFALKRTSDYSLLPTDFIKVIEQIWAIKDIGNTLFIMMYSAPGEWNYKDCSYYYPYHLVRIYDRVPSVTRDTILEGEIFPHLRSQEQIQRDEEMGMYEPLYCPIDDWLSRDPRHVSKWRAFALMEIQDLINEDKGFLPRWHYIHSNQRFIFEVEGISMTRACESYSLFQSLSLKVPMNYDTQLEIDCIQTLDAAQSEDPCDEPYDESDSYWQDMDDETWHNIENMMEG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias626-656Polar residues
Compositional bias970-985Basic and acidic residues
Compositional bias1604-1623Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KT148886
EMBL· GenBank· DDBJ
ALN12435.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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