A0A0S2A4A7 · A0A0S2A4A7_9VIRU
- ProteinRNA-directed DNA polymerase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2597 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
function
Encodes for at least two polypeptides: protease (PR) and reverse transcriptase (RT). The protease processes the polyprotein in cis. Reverse transcriptase is multifunctional enzyme that converts the viral RNA genome into dsDNA in viral cytoplasmic capsids. This enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes in a partially processive 3'- to 5'-endonucleasic mode. Neo-synthesized pregenomic RNA (pgRNA) are encapsidated, and reverse-transcribed inside the nucleocapsid. Partial +DNA is synthesized from the -DNA template and generates the relaxed circular DNA (RC-DNA) genome. After budding and infection, the RC-DNA migrates in the nucleus, and is converted into a plasmid-like covalently closed circular DNA (cccDNA).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | aspartic-type endopeptidase activity | |
Molecular Function | endonuclease activity | |
Molecular Function | nucleic acid binding | |
Molecular Function | RNA-directed DNA polymerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRNA-directed DNA polymerase
- EC number
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Caulimoviridae > Vaccinivirus
Accessions
- Primary accessionA0A0S2A4A7
Proteomes
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 626-656 | Polar residues | ||||
Sequence: QSVNRPSTSGDSKEVPITSEVPSSSTLEGKG | ||||||
Region | 626-660 | Disordered | ||||
Sequence: QSVNRPSTSGDSKEVPITSEVPSSSTLEGKGKTKK | ||||||
Region | 948-994 | Disordered | ||||
Sequence: SKKKGFEKSKINPQKNFKRRFKQKSGKEIEDRKKQSKSKPTSSKGVA | ||||||
Compositional bias | 970-985 | Basic and acidic residues | ||||
Sequence: QKSGKEIEDRKKQSKS | ||||||
Domain | 997-1012 | CCHC-type | ||||
Sequence: CWNCNQQGHFSRECPR | ||||||
Region | 1038-1069 | Disordered | ||||
Sequence: DDYSDTSSIYSLETESDSESSDSDQESEDEDT | ||||||
Region | 1559-1623 | Disordered | ||||
Sequence: QPIESDDEPNDEIQPINDEPNEEVRPGFQPIESNDEPNNEIQPSNDEPNKEVRPKPTKDIRPKPI | ||||||
Compositional bias | 1604-1623 | Basic and acidic residues | ||||
Sequence: DEPNKEVRPKPTKDIRPKPI | ||||||
Domain | 1726-1905 | Reverse transcriptase | ||||
Sequence: ELIQPSKSPHSSPAFCVRNHAEIKRQKARIVINYKELNRVTKDDGYFLPNLETLVYQVAEARVFSKFDCKSGYWQIKLTPESIPLTAFSTPKGQYEWKVLPFGLKNAPNIFQRRMDKIFKDCYQFCGVYVDDILVFSKDKEEHLLHLDIIINKIVQNGIIIGRTKYELVRESIDFLGVTI |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,597
- Mass (Da)301,680
- Last updated2016-02-17 v1
- ChecksumA5051363A24DF6C0
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 626-656 | Polar residues | ||||
Sequence: QSVNRPSTSGDSKEVPITSEVPSSSTLEGKG | ||||||
Compositional bias | 970-985 | Basic and acidic residues | ||||
Sequence: QKSGKEIEDRKKQSKS | ||||||
Compositional bias | 1604-1623 | Basic and acidic residues | ||||
Sequence: DEPNKEVRPKPTKDIRPKPI |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KT148886 EMBL· GenBank· DDBJ | ALN12435.1 EMBL· GenBank· DDBJ | Genomic DNA |