A0A0S1VWZ9 · A0A0S1VWZ9_HEV
- ProteinNon-structural polyprotein pORF1
- GeneORF1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1702 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Y-domain: Indispensable for virus replication.
Catalytic activity
- GTP + S-adenosyl-L-methionine = N7-methyl-GTP + S-adenosyl-L-homocysteineThis reaction proceeds in the forward direction.
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | host cell cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | cysteine-type peptidase activity | |
Molecular Function | helicase activity | |
Molecular Function | metal ion binding | |
Molecular Function | mRNA methyltransferase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Biological Process | DNA-templated transcription | |
Biological Process | mRNA modification | |
Biological Process | proteolysis | |
Biological Process | RNA processing | |
Biological Process | viral protein processing | |
Biological Process | viral RNA genome replication |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNon-structural polyprotein pORF1
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Alsuviricetes > Hepelivirales > Hepeviridae > Orthohepevirinae > Paslahepevirus
- Virus hosts
Accessions
- Primary accessionA0A0S1VWZ9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Interaction
Subunit
The protease domain interacts with host EIF2AK4 (via C-terminus); this interaction inhibits dimerization of EIF2AK4 and prevents EIF2AK4-mediated phosphorylation of host EIF2A.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 56-240 | Alphavirus-like MT | ||||
Sequence: VLRPEVLWNHPIQRVIHNELEQYCRTRAGRCLEVGAHPRFINDNPNVLHRCFLRPVGRDVQRWYSAPTSGPAGNCRRSALRGLPPVDRTYCFDGFSRCAFAAETGVALYSLHDLWPADVAEAMARDGMPRLYAALHLPPEVLLPPGTYHTTSYLQIHDGNRAVVTYEGDTSAGYNHEVSILRAWI | ||||||
Region | 711-730 | Disordered | ||||
Sequence: SSDFSPPEAADSAPAATPGL | ||||||
Region | 737-788 | Disordered | ||||
Sequence: VSDIWVLPPPSEGSQVDAVPVPPASEPAGLPSSTEPPPPVRKPPAPPPSRTR | ||||||
Compositional bias | 760-786 | Pro residues | ||||
Sequence: ASEPAGLPSSTEPPPPVRKPPAPPPSR | ||||||
Domain | 785-931 | Macro | ||||
Sequence: SRTRRLLYTYPDGARVYAGSLFESDCDWLVNASNPGHRPGGGLCHAFYQRFPEAFYPTEFVMREGLAAYTLTPRPIIHAVAPDYRAEQNPKRIEAAYRETCSRRGTAAYPLLGAGIYQVPVSLSFDAWERNHRHGDELYLTEPAATS | ||||||
Domain | 956-1225 | +RNA virus helicase C-terminal | ||||
Sequence: LDIDAATDVGRACAGCTISRGVVHYQFTAGVPGSGKSRSIQRGEVDVVVVPTREHRNSWRRRGFEAFTPHTAARVTTGCRVVIDEAPSLPPHLLLHMQRASSVHLLGDPNQIPAIDFEHAGLVPAIRPELARTSWWHVTHRCPADVCELVRGDYPKIQTTSRVLRSLLWNEPAIGQKLVFTHAAKAANPGAITVHEAQGATFTETTIIATADARGLIQSSRAHAIVALTRHTEKCVILDAPGLLREVGISDVIVNNFFLAGGEVGHHGPS | ||||||
Domain | 1463-1574 | RdRp catalytic | ||||
Sequence: CMVFENDFSEFDSTQNNFSLGLECVVMEDCGMPQWLIRLYHLVRSAWILQAPMESLKGFWKKHSGEPGTLLWNTVWIMAIIAHCYEFRDIRVAAFKGDDSVVLCSDYRQSRN |
Sequence similarities
Belongs to the hepevirus non-structural polyprotein family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,702
- Mass (Da)186,671
- Last updated2016-02-17 v1
- ChecksumD85DC51CF318F5EA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 760-786 | Pro residues | ||||
Sequence: ASEPAGLPSSTEPPPPVRKPPAPPPSR |