A0A0R5RP31 · A0A0R5RP31_MOUSE
- ProteinSodium channel protein
- GeneScn5a
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1966 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated sodium channel complex | |
Molecular Function | voltage-gated sodium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium channel protein
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionA0A0R5RP31
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 127-149 | Helical | ||||
Sequence: ILVHSLFSMLIMCTILTNCVFMA | ||||||
Transmembrane | 253-273 | Helical | ||||
Sequence: VMVLTVFCLSVFALIGLQLFM | ||||||
Transmembrane | 388-416 | Helical | ||||
Sequence: IYMIFFMLVIFLGSFYLVNLILAVVAMAY | ||||||
Transmembrane | 718-736 | Helical | ||||
Sequence: FADLTITMCIVLNTLFMAL | ||||||
Transmembrane | 748-771 | Helical | ||||
Sequence: MLQVGNLVFTGIFTAEMTFKIIAL | ||||||
Transmembrane | 783-807 | Helical | ||||
Sequence: IFDSIIVILSLMELGLSRVGNLSVL | ||||||
Transmembrane | 828-861 | Helical | ||||
Sequence: LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF | ||||||
Transmembrane | 918-941 | Helical | ||||
Sequence: LLVFLLVMVIGNLVVLNLFLALLL | ||||||
Transmembrane | 1154-1173 | Helical | ||||
Sequence: SWFETFIIFMILLSSGALAF | ||||||
Transmembrane | 1194-1210 | Helical | ||||
Sequence: MFTYVFVLEMLLKWVAY | ||||||
Transmembrane | 1222-1243 | Helical | ||||
Sequence: WLDFLIVDVSLVSLMANTLGFA | ||||||
Transmembrane | 1271-1297 | Helical | ||||
Sequence: VVVNALVGAIPSIMNVLLVCLIFWLIF | ||||||
Transmembrane | 1393-1419 | Helical | ||||
Sequence: LYMYIYFVVFIIFGSFFTLNLFIGVII | ||||||
Transmembrane | 1478-1496 | Helical | ||||
Sequence: AFDVTIMFLICLNMVTMMV | ||||||
Transmembrane | 1508-1530 | Helical | ||||
Sequence: ILAKINLLFVAIFTGECIVKMAA | ||||||
Transmembrane | 1542-1561 | Helical | ||||
Sequence: IFDFVVVILSIVGTVLSDII | ||||||
Transmembrane | 1595-1623 | Helical | ||||
Sequence: LLFALMMSLPALFNIGLLLFLVMFIYSIF | ||||||
Transmembrane | 1698-1721 | Helical | ||||
Sequence: ILFFTTYIIISFLIVVNMYIAIIL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 27-68 | Disordered | ||||
Sequence: RMAEKQARGSATSQESREGLPEEEAPRPQLDLQASKKLPDLY | ||||||
Domain | 130-422 | Ion transport | ||||
Sequence: HSLFSMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGIVWNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQA | ||||||
Coiled coil | 413-451 | |||||
Sequence: AMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIR | ||||||
Region | 461-567 | Disordered | ||||
Sequence: LEMSPLAPVTNHERRSKRRKRLSSGTEEGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHRTSLLVPWPL | ||||||
Compositional bias | 480-500 | Basic and acidic residues | ||||
Sequence: KRLSSGTEEGGDDRLPKSDSE | ||||||
Compositional bias | 503-526 | Polar residues | ||||
Sequence: PRALNQLSLTHGLSRTSMRPRSSR | ||||||
Domain | 508-667 | Voltage-gated Na+ ion channel cytoplasmic | ||||
Sequence: QLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHRTSLLVPWPLRRPSTQGQPGFGTSAPGHVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSHLLRPIVLDRPPDTTTPSEEPGGPQMLTPQAPCADGFEEPGARQRALSAVS | ||||||
Region | 619-650 | Disordered | ||||
Sequence: LRPIVLDRPPDTTTPSEEPGGPQMLTPQAPCA | ||||||
Domain | 718-947 | Ion transport | ||||
Sequence: FADLTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRVGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSAD | ||||||
Domain | 955-1149 | Sodium ion transport-associated | ||||
Sequence: DGEMNNLQLALARIQRGLRFVKRTTWDFCCGLLRRRPKKPAALATHSQLPSCIAAPRSPPPPEVEKAPPARKETRFEEDKRPGQGTPGDTEPVCVPIAVAESDTDDQGEDEENSLGTEEEESSKQTPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTTQAPGKVWWRLRKTCYR | ||||||
Region | 1001-1095 | Disordered | ||||
Sequence: SQLPSCIAAPRSPPPPEVEKAPPARKETRFEEDKRPGQGTPGDTEPVCVPIAVAESDTDDQGEDEENSLGTEEEESSKQTPEDSYSEGSTADMTN | ||||||
Compositional bias | 1020-1039 | Basic and acidic residues | ||||
Sequence: KAPPARKETRFEEDKRPGQG | ||||||
Compositional bias | 1057-1071 | Acidic residues | ||||
Sequence: DTDDQGEDEENSLGT | ||||||
Domain | 1153-1428 | Ion transport | ||||
Sequence: HSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLMANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSGCESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKK | ||||||
Domain | 1477-1731 | Ion transport | ||||
Sequence: QAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKMAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYSFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEES | ||||||
Region | 1905-1966 | Disordered | ||||
Sequence: NFSRRSGPPSSSSISSTSFPPSYDSVTRATSDNLPVRASDYSRSEDLADFPPSPDRDRESIV | ||||||
Compositional bias | 1907-1942 | Polar residues | ||||
Sequence: SRRSGPPSSSSISSTSFPPSYDSVTRATSDNLPVRA |
Sequence similarities
Belongs to the sodium channel (TC 1.A.1.10) family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,966
- Mass (Da)221,604
- Last updated2016-02-17 v1
- Checksum4F8C4B8C5434E00A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 480-500 | Basic and acidic residues | ||||
Sequence: KRLSSGTEEGGDDRLPKSDSE | ||||||
Compositional bias | 503-526 | Polar residues | ||||
Sequence: PRALNQLSLTHGLSRTSMRPRSSR | ||||||
Compositional bias | 1020-1039 | Basic and acidic residues | ||||
Sequence: KAPPARKETRFEEDKRPGQG | ||||||
Compositional bias | 1057-1071 | Acidic residues | ||||
Sequence: DTDDQGEDEENSLGT | ||||||
Compositional bias | 1907-1942 | Polar residues | ||||
Sequence: SRRSGPPSSSSISSTSFPPSYDSVTRATSDNLPVRA |