Results suggest that variations of estrogen alpha/beta receptor levels are associated with differences in social interaction through the OT and AVP systems by upregulating gene expression for those peptides and the oxytocin and vasopressin 1a receptors.
ERbeta plays a role in the induction of the cAMP pathway in mouse granulosa cells and disruption of proper ERbeta signaling associated with this pathway may cause negative effects on ovulation and fertility.
The results suggest ERalpha ERbeta and AR distribution and expression are not sex dependent in the mouse heart. ERbeta expression were similar in both heart chambers.
ERalpha induced leptin expression and ERbeta inhibited its expression in 3T3-L1 adipocytes. The ratio of the ERalpha-to-ERbeta expression in 3T3-L1 adipocytes may be an important potential regulatory factor in leptin expression.
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