A0A0R4IZR5 · A0A0R4IZR5_DANRE
- ProteinCohesin subunit SA
- Genestag2b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1276 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | chromosome, centromeric region | |
Cellular Component | cohesin complex | |
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Biological Process | cell division | |
Biological Process | chromosome segregation | |
Biological Process | regulation of hematopoietic progenitor cell differentiation | |
Biological Process | regulation of vasculogenesis | |
Biological Process | sister chromatid cohesion |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCohesin subunit SA
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A0R4IZR5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Interaction
Subunit
Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-68 | Disordered | ||||
Sequence: MIAAPELQTEFHYPQDTDTRFSSDTDFDDPDGRNAIIGKGKAKKGKKGPGEKGKGMGKGVGRMNGHHQ | ||||||
Compositional bias | 17-38 | Basic and acidic residues | ||||
Sequence: TDTRFSSDTDFDDPDGRNAIIG | ||||||
Coiled coil | 227-280 | |||||
Sequence: ALNLSINMDNTQRQYEAERNKMIGKRANDRLELLLQKRKELQENQDEIENMMNA | ||||||
Domain | 286-371 | SCD | ||||
Sequence: FVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYHNRELNAKLELFTSRFKDRIVSM | ||||||
Compositional bias | 1043-1065 | Polar residues | ||||
Sequence: AGGDDDTMSVVSGISSRGSSVRS | ||||||
Region | 1043-1107 | Disordered | ||||
Sequence: AGGDDDTMSVVSGISSRGSSVRSKKAKPATAKRKLPEEESSSSSEVWMSREQSMQTPVMMPSPHL | ||||||
Compositional bias | 1083-1105 | Polar residues | ||||
Sequence: SSSSEVWMSREQSMQTPVMMPSP | ||||||
Region | 1133-1152 | Disordered | ||||
Sequence: DQQQQHTHPHTPQPQHHQTP | ||||||
Region | 1229-1248 | Disordered | ||||
Sequence: FDTMDIDLPPSKNRRERSEL |
Sequence similarities
Belongs to the SCC3 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,276
- Mass (Da)146,551
- Last updated2016-01-20 v1
- Checksum2548B6371ABACBC2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E7FE97 | E7FE97_DANRE | stag2b | 1269 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 17-38 | Basic and acidic residues | ||||
Sequence: TDTRFSSDTDFDDPDGRNAIIG | ||||||
Compositional bias | 1043-1065 | Polar residues | ||||
Sequence: AGGDDDTMSVVSGISSRGSSVRS | ||||||
Compositional bias | 1083-1105 | Polar residues | ||||
Sequence: SSSSEVWMSREQSMQTPVMMPSP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX088535 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR626891 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |