A0A0R4IZR5 · A0A0R4IZR5_DANRE

Function

function

Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentchromosome, centromeric region
Cellular Componentcohesin complex
Cellular Componentnucleus
Molecular Functionchromatin binding
Biological Processcell division
Biological Processchromosome segregation
Biological Processregulation of hematopoietic progenitor cell differentiation
Biological Processregulation of vasculogenesis
Biological Processsister chromatid cohesion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cohesin subunit SA
  • Alternative names
    • SCC3 homolog
    • Stromal antigen

Gene names

    • Name
      stag2b

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A0R4IZR5
  • Secondary accessions
    • A0A8M9Q574

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Subunit

Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, coiled coil, domain.

TypeIDPosition(s)Description
Region1-68Disordered
Compositional bias17-38Basic and acidic residues
Coiled coil227-280
Domain286-371SCD
Compositional bias1043-1065Polar residues
Region1043-1107Disordered
Compositional bias1083-1105Polar residues
Region1133-1152Disordered
Region1229-1248Disordered

Sequence similarities

Belongs to the SCC3 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,276
  • Mass (Da)
    146,551
  • Last updated
    2016-01-20 v1
  • Checksum
    2548B6371ABACBC2
MIAAPELQTEFHYPQDTDTRFSSDTDFDDPDGRNAIIGKGKAKKGKKGPGEKGKGMGKGVGRMNGHHQENGMENVMLFEVVRLGKSAMQSVVDDWIESYKHDRDVALLDLINFFIQCSGCKGVVSGEMFRNMQNSEIIRKMTEEFDEDSGDYPLTMTGPQWKKFKSSFCEFIGVLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSINMDNTQRQYEAERNKMIGKRANDRLELLLQKRKELQENQDEIENMMNAIFKGVFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTMHDKQGEVRLKCLTALQGLYHNRELNAKLELFTSRFKDRIVSMTLDKEYDVAVQAIKLLTLVLHSSDEVLTAEDCESVYHLVYSAHRPVAVAAGEFLFKKLFSHRDPEDDSMPKRRGRQSVNANLIKTTVFFFLESELHEHAAYLVDSMWDCAAELLKDWECMISLLLDEPLPGEEALTDRQETALIEILLCTIRQAAECHPPVGRGTGKRVLTAKEKKTQLDDRTRMTELFAIALPALLAKYSVDAEKVTNLLQLPQFFDLEIYTTGRLEKHLDSLLRQIREIVEKHTDTDVLEACSKTYHSLCNEEFTIFNRVDIARSQLLDEQVDKFNKLLEDFLQEGEDPDEDDAYQVLSTLKRISAFYNAHDLSKWDLFTSNYKLLNTGIENGDMPEQIVVHALQCTHYVILWSLAKVSEGCYKKEDMLTLRKQMRAFCLMCQRYLTSVNTAVKEQAFTILCDLLLIFSHQIISGGREALEPLVYTPEASLQSELLNFILDHVFIDQDEDSNSTDGQQDDEAGKIEALHKRRNLLAAYCKLIIYNVVEMSTGADIFKQYMRYYNDYGDIIKETMSKTRQIDKIQCAKTLILSLQQLFNEMLSELGPSFDRSSSAFCGIKELARRFSLTFGLDQLKTREAIAMLHKDGIEFAFKEANPQGDGHPPLNLAFLDILSEFSSKLMRQDKRTVHMYLERFMTFQMALQREDCWLPLISYRNSLQAGGDDDTMSVVSGISSRGSSVRSKKAKPATAKRKLPEEESSSSSEVWMSREQSMQTPVMMPSPHLTSTIMREPKRLRPEESYMGVYTMTPDQQQQHTHPHTPQPQHHQTPMDYNTQVTWMLAQRQQQEEVARQQQERAMNYAKLRSNLQHAIRRGTGLMEDDEEPIVEDVMMSSEGRIEDLNEGMDFDTMDIDLPPSKNRRERSELKPDFFDPASIMDESVRSTHFLGYDAFQR

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E7FE97E7FE97_DANREstag2b1269

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias17-38Basic and acidic residues
Compositional bias1043-1065Polar residues
Compositional bias1083-1105Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX088535
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CR626891
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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