A0A0R4IWH3 · A0A0R4IWH3_DANRE
- ProteinTyrosine-protein phosphatase non-receptor type 13
- Geneptpn13
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2317 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling.
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 2216 | substrate | ||||
Sequence: D | ||||||
Active site | 2246 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 2246-2252 | substrate | ||||
Sequence: CSAGIGR | ||||||
Binding site | 2290 | substrate | ||||
Sequence: Q |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Cellular Component | nucleus | |
Molecular Function | phosphatidylinositol 3-kinase regulatory subunit binding | |
Molecular Function | protein tyrosine phosphatase activity |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein phosphatase non-receptor type 13
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A0R4IWH3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-187 | KIND | ||||
Sequence: VSLAEALEVRGGPLQEEEVWAVLNQSAESLHELLRRADPTALGFIISPWSLLLMPSGNISFTDENVTQKDLRAFTPPEVLDGLNLSSLSDMEKMHMYSLGMTLFWGADYEIPQSQPMELGEHLNSVLLNMCDDSTLTRLSVRSVLDTCSAHIRTSNCDPSFSYVRRLVRLVLGSLSQLDGLLSQT | ||||||
Region | 327-354 | Disordered | ||||
Sequence: ARRGSSALSTRSAGRHKPSSKARDSRYS | ||||||
Region | 396-453 | Disordered | ||||
Sequence: AIDDPHTHRRYNSDYSSSSESPSVTSSDPDYRQAKKSEDLRRFSSQVGLSDHDGVSLS | ||||||
Compositional bias | 409-425 | Polar residues | ||||
Sequence: DYSSSSESPSVTSSDPD | ||||||
Compositional bias | 426-441 | Basic and acidic residues | ||||
Sequence: YRQAKKSEDLRRFSSQ | ||||||
Domain | 554-853 | FERM | ||||
Sequence: RKVGVVLLNGQKLELCCDVKAVCKDVLDMVVAHIGLVEHHLFSLAYLKDDEFYFVESDAKLSKVAPDGWKDDPKKKKTDVIFNLFLRIKFFQDDVSLIQHTMTKHQYYLQLRKDILEERVRCDLENAMILASLALQAEFGDYQTELHGKTYFRTEHYLPAPVLDKIDQTTIKEELPKLHSSYYNASEQEAELEFLKVCQRLPEYGVHFHRVLPEKRSLTGIMLGIYSKGVLIFEVLNGNRTPVLRFPWRDTKKISFTKKKICLQNTSDGIKHLFQTDSQKTCQYLLQLCSAQYKFHLHMK | ||||||
Compositional bias | 903-938 | Polar residues | ||||
Sequence: SKSSSSRVSVPSEPPYPGFSSSSNPRMKSRSHHNLG | ||||||
Region | 903-1012 | Disordered | ||||
Sequence: SKSSSSRVSVPSEPPYPGFSSSSNPRMKSRSHHNLGQLPESPEHRMVPFSSQSQSSMARSQVLASSHQRANSDTGSIAVARQQESLSVDDSPRWSPKSLKKESDSSSCED | ||||||
Compositional bias | 948-994 | Polar residues | ||||
Sequence: MVPFSSQSQSSMARSQVLASSHQRANSDTGSIAVARQQESLSVDDSP | ||||||
Domain | 1058-1144 | PDZ | ||||
Sequence: TVNLKKDVKYGLGFQVVGGESSGRQDLGTFISSITPGGPADLNGLLKPGDRLLSVNDVSLESLSHTTVVEMLQSAPDDVSLVVSQPK | ||||||
Region | 1168-1210 | Disordered | ||||
Sequence: DMDSSSEDHTRSPSPPFTASKTSPPQSIRQGSISSQDSKTESA | ||||||
Compositional bias | 1176-1210 | Polar residues | ||||
Sequence: HTRSPSPPFTASKTSPPQSIRQGSISSQDSKTESA | ||||||
Region | 1242-1289 | Disordered | ||||
Sequence: SIEAMPPALPPKTRKAKAADVPKELEYSDRGDSDMDEDTYSNSQDKLK | ||||||
Compositional bias | 1257-1286 | Basic and acidic residues | ||||
Sequence: AKAADVPKELEYSDRGDSDMDEDTYSNSQD | ||||||
Domain | 1320-1397 | PDZ | ||||
Sequence: DIELSKIDSSLGISVTGGSNTSLKHGGIYVKGVIPKGAAEQDGRIKKGDRVVAVNGKSLEGATHKQAVEMLRDTGQEV | ||||||
Region | 1426-1457 | Disordered | ||||
Sequence: AITTPVPSPRKQAHLQPQASPRTSSSPQESQR | ||||||
Compositional bias | 1430-1457 | Polar residues | ||||
Sequence: PVPSPRKQAHLQPQASPRTSSSPQESQR | ||||||
Region | 1495-1518 | Disordered | ||||
Sequence: AANLERDSSAYQTPAERVSYEDEM | ||||||
Domain | 1588-1668 | PDZ | ||||
Sequence: KVSLVKSDKGSLGFTLTKGTDENCYIHDIIQDPAKGDGRLRPGDRMIMVNNTDVSGMNHTEVVNLVRAAPKVVDLVVGRIL | ||||||
Domain | 1682-1765 | PDZ | ||||
Sequence: DITFQCHDESLGLVLDGGSDSALGVLYVKEIFPGSAAFEEGSLRHLDIIHYINGVPTQDLTLSESRRLLQLSLRNLSLKATRDG | ||||||
Domain | 1817-1897 | PDZ | ||||
Sequence: KLELEKPPAGGLGFSVIGGERGIFVKSVTPGGTADIAGTLQVGDRLLKVNDDLMIGVSHAKAVTTIRKAKGLVQLIVSRPP | ||||||
Region | 1916-1995 | Disordered | ||||
Sequence: NGNNDYDTGSLEKRKGTDTSADLSEDTDCDGSSLPEDSPETSRKAEWKEENVDAPLNDSAPQSSSGPLDEDEITWGSDDL | ||||||
Compositional bias | 1923-1937 | Basic and acidic residues | ||||
Sequence: TGSLEKRKGTDTSAD | ||||||
Compositional bias | 1952-1968 | Basic and acidic residues | ||||
Sequence: DSPETSRKAEWKEENVD | ||||||
Compositional bias | 1971-1985 | Polar residues | ||||
Sequence: LNDSAPQSSSGPLDE | ||||||
Domain | 2051-2305 | Tyrosine-protein phosphatase | ||||
Sequence: PLQEFENLQNLRPLDECLIGQTKENKKKNRYKNIVPFDTTRVLLGNDGGYINANFIKMAVKDESFMYIACQGPLPTTLGDFWQMVWEQKSNVIAMMTQEVEGGKVKCQRYWPDTPRSPQMVDDRLQVTLVKDQHLDNFVIRLIELKDVQTNELQRVTHLNYTGWPDHGTPTQPEQLLTFISYMRHIHLSGPIITHCSAGIGRSGTLICIDVVLGLISKDADFDISDIVRTMRLQRQGMVQTEEQYIFCYQVILYV | ||||||
Domain | 2227-2296 | Tyrosine specific protein phosphatases | ||||
Sequence: LTFISYMRHIHLSGPIITHCSAGIGRSGTLICIDVVLGLISKDADFDISDIVRTMRLQRQGMVQTEEQYI |
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,317
- Mass (Da)256,777
- Last updated2016-01-20 v1
- Checksum77140F407F9CC427
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2B8N1 | A0A8M2B8N1_DANRE | ptpn13 | 2480 | ||
A0A8M3ALY6 | A0A8M3ALY6_DANRE | ptpn13 | 2455 | ||
A0A8M3AL92 | A0A8M3AL92_DANRE | ptpn13 | 2432 | ||
A0A0R4IPR0 | A0A0R4IPR0_DANRE | ptpn13 | 2475 | ||
A0A8M3ATM7 | A0A8M3ATM7_DANRE | ptpn13 | 2460 | ||
A0A8M3B4I1 | A0A8M3B4I1_DANRE | ptpn13 | 1353 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 409-425 | Polar residues | ||||
Sequence: DYSSSSESPSVTSSDPD | ||||||
Compositional bias | 426-441 | Basic and acidic residues | ||||
Sequence: YRQAKKSEDLRRFSSQ | ||||||
Compositional bias | 903-938 | Polar residues | ||||
Sequence: SKSSSSRVSVPSEPPYPGFSSSSNPRMKSRSHHNLG | ||||||
Compositional bias | 948-994 | Polar residues | ||||
Sequence: MVPFSSQSQSSMARSQVLASSHQRANSDTGSIAVARQQESLSVDDSP | ||||||
Compositional bias | 1176-1210 | Polar residues | ||||
Sequence: HTRSPSPPFTASKTSPPQSIRQGSISSQDSKTESA | ||||||
Compositional bias | 1257-1286 | Basic and acidic residues | ||||
Sequence: AKAADVPKELEYSDRGDSDMDEDTYSNSQD | ||||||
Compositional bias | 1430-1457 | Polar residues | ||||
Sequence: PVPSPRKQAHLQPQASPRTSSSPQESQR | ||||||
Compositional bias | 1923-1937 | Basic and acidic residues | ||||
Sequence: TGSLEKRKGTDTSAD | ||||||
Compositional bias | 1952-1968 | Basic and acidic residues | ||||
Sequence: DSPETSRKAEWKEENVD | ||||||
Compositional bias | 1971-1985 | Polar residues | ||||
Sequence: LNDSAPQSSSGPLDE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR628389 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR678270 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CU459214 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CU571388 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |