A0A0R4IVA6 · A0A0R4IVA6_DANRE
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Geneplcb3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1245 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | calcium ion binding | |
Molecular Function | calmodulin binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | cartilage morphogenesis | |
Biological Process | embryonic viscerocranium morphogenesis | |
Biological Process | G protein-coupled receptor signaling pathway | |
Biological Process | lipid catabolic process | |
Biological Process | negative regulation of calcium ion import | |
Biological Process | negative regulation of vascular permeability | |
Biological Process | phosphatidylinositol metabolic process | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A0R4IVA6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 468-558 | Disordered | ||||
Sequence: NKKKHHHRASNGGSIRRKDGTDEQSSPLNDCPLSDGDVGQLMSNGGEKLAERMAKDHDNSKSIDRGDGESDEEEEEEPIPDPKKHNNTDEG | ||||||
Compositional bias | 516-534 | Basic and acidic residues | ||||
Sequence: LAERMAKDHDNSKSIDRGD | ||||||
Domain | 570-686 | PI-PLC Y-box | ||||
Sequence: MSTLVNYIEPVKFKSFEVAAKRKKFFEMSSFVETKGMDTLKNSPTEFVEYNKKQMSRIYPKGTRVDSSNYMPQLFWNVGCQMVALNFQTLDLAMQLNMGVFEYNGRCGYLLKPEFMR | ||||||
Domain | 689-813 | C2 | ||||
Sequence: DKHFDPFTTDIVDGIVANTVKVKIISGQFLNDKKVGVYVEVDMFGLPADTKRKYRTKTSNNNSLDPVWDDETFVFNKVVLPTLASLRVAVYEENGKFIGHRILPVSALRPGYHYICLKNELNQPL | ||||||
Region | 862-913 | Disordered | ||||
Sequence: DPTEGGPTKQEEGDGTDSSCVTSADPIFPLPSSPTLPSVPTDLNPPPSGQKE | ||||||
Compositional bias | 873-890 | Polar residues | ||||
Sequence: EGDGTDSSCVTSADPIFP | ||||||
Compositional bias | 891-905 | Pro residues | ||||
Sequence: LPSSPTLPSVPTDLN | ||||||
Coiled coil | 1046-1114 | |||||
Sequence: LKEANQKLKDIAIECQAAQIKKLKDVCDKEKKELQKMLDRKRLNSIVEARKAEKEIRDVNEINRKHIQE | ||||||
Region | 1177-1216 | Disordered | ||||
Sequence: LESKGSRKDSLMGQTNDGPNSGPPSNCSTPPYSSPNHSWS | ||||||
Compositional bias | 1184-1199 | Polar residues | ||||
Sequence: KDSLMGQTNDGPNSGP | ||||||
Region | 1226-1245 | Disordered | ||||
Sequence: LDSSTSSSSAKSETDTTGVY |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,245
- Mass (Da)141,928
- Last updated2018-06-20 v2
- Checksum480D03E87F249665
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A2TJ25 | A2TJ25_DANRE | plcb3 | 1244 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 516-534 | Basic and acidic residues | ||||
Sequence: LAERMAKDHDNSKSIDRGD | ||||||
Compositional bias | 873-890 | Polar residues | ||||
Sequence: EGDGTDSSCVTSADPIFP | ||||||
Compositional bias | 891-905 | Pro residues | ||||
Sequence: LPSSPTLPSVPTDLN | ||||||
Compositional bias | 1184-1199 | Polar residues | ||||
Sequence: KDSLMGQTNDGPNSGP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL772136 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX511143 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |