A0A0R4IPH3 · A0A0R4IPH3_DANRE

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentplasma membrane
Molecular Functionchemorepellent activity
Molecular Functiongrowth factor activity
Molecular Functionprotein tyrosine kinase activator activity
Biological Processanimal organ development
Biological Processcardiac neuron development
Biological Processcell differentiation
Biological Processenteric nervous system development
Biological Processeurydendroid cell differentiation
Biological Processfin regeneration
Biological Processgeneration of neurons
Biological Processintracellular signal transduction
Biological Processnervous system development
Biological Processneural crest cell migration
Biological Processoligodendrocyte cell fate specification
Biological Processperipheral nervous system development
Biological ProcessSchwann cell development
Biological ProcessSchwann cell migration
Biological Processventricular trabecula myocardium morphogenesis

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Neuregulin 1
    • Pro-neuregulin-1, membrane-bound isoform isoform IIb1

Gene names

    • Name
      nrg1
    • Synonyms
      wu:fm70e01

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A0R4IPH3
  • Secondary accessions
    • A0A8M1NZW6

Proteomes

    • Identifier
    • Component
      Alternate scaffold 10, Chromosome 10

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane
; Single-pass type I membrane protein
Secreted

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane333-355Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond305↔314

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain161-254Ig-like
Domain271-315EGF-like
Region419-438Disordered
Compositional bias516-552Polar residues
Region516-606Disordered
Compositional bias570-588Polar residues
Compositional bias618-656Polar residues
Region618-675Disordered

Sequence similarities

Belongs to the neuregulin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    722
  • Mass (Da)
    78,783
  • Last updated
    2016-01-20 v1
  • Checksum
    DFC9197C034155C3
MAILPGRSSSLTVSVLYGAAVCLSLWTRVVRCGSFACSPPGASVQELARRSGVVFEGKLQEEERAERNWTETPMNASRQVRVRVQQVWQLKAGGLIKDSVVSLVWFEGGRCFQLNTGIRYMFFIEPTNDTSVFTAVFPPVETKRTVRKDVSQVLCQDCAEPKLKNLRSVTVEDGKKTVLKCEILAGNPAPNVKWYKNGKELTGKNKPKSIKIKKKKQGKISELLIRKSTEGDAGLYTCEAVNSLGKTNTTANLFIINTATSTTPSAKTSSHVTPCNESEKEYCVNHGKCFTLEVTPGNIRRLCRCPNEFTGDRCQHYVMASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRERNAAAKGPQHPHPPPENLQLVNHYMPTNPVPAHMTDKEAETSLSTNEFTSPTHPSTAITHSSSQCWSNGKAESVVSDSHAVLMKPSAENCQHGTPSHRGRLNATGGVHQLNDYLKNSREAQGSNRDSPYSERYVSAMTTPTRLSPVGLLSPVTPSSPPSEMSAPLSSLATSVPSMLTSPSGEEERPLLFRTPPILRDKSASTQGRKSGHNLRNSAHYNHGLDIPSPPPSPLHIEEEIDCLEQYKSTSVPSSAPHSPSAARTQPSGQAAPEQAVSGSNSESSSSESETEDERVGEDTPFLGLQNPLAAGSLVLDGLEGSRTNPALHLSPQHELQNRLTAVMANQDPIAV

Computationally mapped potential isoform sequences

There are 11 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0R4IBM0A0A0R4IBM0_DANREnrg1730
A0A8M3B1T9A0A8M3B1T9_DANREnrg1729
A0A8M3B1W6A0A8M3B1W6_DANREnrg1724
A0A0R4IDP7A0A0R4IDP7_DANREnrg1725
A0A1B4Z255A0A1B4Z255_DANREnrg1604
A0A8M3B955A0A8M3B955_DANREnrg1692
A0A0R4IFE6A0A0R4IFE6_DANREnrg1687
B3DK99B3DK99_DANREnrg1599
A0A8M9QGQ0A0A8M9QGQ0_DANREnrg1404
A0A8M6Z0Q7A0A8M6Z0Q7_DANREnrg1412
A0A8M9QKS2A0A8M9QKS2_DANREnrg1417

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias516-552Polar residues
Compositional bias570-588Polar residues
Compositional bias618-656Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX321906
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BX537303
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CR855879
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CU459101
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp