Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A0R1E7R9 · A0A0R1E7R9_DROYA

Function

function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentcell cortex
Cellular Componentcell surface
Cellular Componentciliary rootlet
Cellular Componentdendritic shaft
Cellular Componentendoplasmic reticulum membrane
Cellular Componentgamma-secretase complex
Cellular ComponentGolgi membrane
Cellular Componentgrowth cone
Cellular Componentlate endosome
Cellular Componentlysosomal membrane
Cellular Componentmembrane raft
Cellular Componentmitochondrial inner membrane
Cellular Componentneuromuscular junction
Cellular Componentneuronal cell body
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Cellular Componentrecycling endosome
Cellular ComponentZ disc
Molecular Functionaspartic endopeptidase activity, intramembrane cleaving
Molecular Functionprotein homodimerization activity
Biological Processamyloid-beta formation
Biological Processapoptotic process
Biological Processassociative learning
Biological Processcalcium ion transport
Biological Processcopper ion import
Biological Processmembrane protein ectodomain proteolysis
Biological Processnegative regulation of apoptotic process
Biological ProcessNotch receptor processing, ligand-dependent
Biological Processprotein processing
Biological Processregulation of heart rate
Biological Processregulation of Notch signaling pathway
Biological Processshort-term memory
Biological Processwing disc dorsal/ventral pattern formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Presenilin
  • EC number

Gene names

    • Name
      Dyak\GE23235
    • ORF names
      Dyak_GE23235

Organism names

  • Taxonomic identifier
  • Strains
    • Tai18E2
    • Tai18E2 / Tucson 14021-0261.01
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    A0A0R1E7R9

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane104-128Helical
Transmembrane148-173Helical
Transmembrane180-201Helical
Transmembrane213-232Helical
Transmembrane244-260Helical
Transmembrane478-499Helical
Transmembrane505-524Helical

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias1-19Polar residues
Region1-52Disordered
Region67-88Disordered
Compositional bias324-352Polar residues
Region324-377Disordered
Compositional bias361-375Polar residues
Compositional bias418-442Polar residues
Region418-446Disordered

Domain

The PAL motif is required for normal active site conformation.

Sequence similarities

Belongs to the peptidase A22A family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    538
  • Mass (Da)
    58,940
  • Last updated
    2016-01-20 v1
  • MD5 Checksum
    394166ADA5CD7597ABFF45D8308FFAB9
MAAVNLQASCSSGLASEDDANVGSQIGEAERLERPPRRQQPRNNYGSSNQDQPDAAILAVPNVVMREPSGPRSSRLPGGGGGGASGELEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGLRTGNSHPRQNQRDDGSVLATEGMPLVTFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVVKPFMEDLSAKQVFI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-19Polar residues
Compositional bias324-352Polar residues
Compositional bias361-375Polar residues
Compositional bias418-442Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH891902
EMBL· GenBank· DDBJ
KRK05349.1
EMBL· GenBank· DDBJ
Genomic DNA
CH891902
EMBL· GenBank· DDBJ
KRK05352.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help