A0A0Q9XGI6 · A0A0Q9XGI6_DROMO
- ProteinO-acyltransferase
- GeneDmoj\GI14192
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids576 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+ = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2OThis reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- 1,3-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- 1-O-(9Z-octadecenyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- 1-O-(9Z-octadecyl)-3-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1-O-(9Z-octadecenyl)-2,3-di-(9Z-octadecenoyl)glycerol + CoAThis reaction proceeds in the forward direction.
- 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-3-(9Z)-octadecenoyl-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- 2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoyl-CoA = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + CoAThis reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + hexadecanoyl-CoA = 1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- 13-cis-retinol + hexadecanoyl-CoA = 13-cis-retinyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
- 2-(9Z-octadecenoyl)-glycerol + hexadecanoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CoAThis reaction proceeds in the forward direction.
- all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
- hexadecan-1-ol + hexadecanoyl-CoA = hexadecanyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
- hexadecane-1,2-diol + 2 hexadecanoyl-CoA = 1,2-O,O-dihexadecanoyl-1,2-hexadecanediol + 2 CoAThis reaction proceeds in the forward direction.
- hexadecane-1,2-diol + hexadecanoyl-CoA = 2-hydroxyhexadecyl hexadecanoate + CoAThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; glycerolipid metabolism.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 497 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | diacylglycerol O-acyltransferase activity | |
Molecular Function | retinol O-fatty-acyltransferase activity | |
Biological Process | negative regulation of lipid storage | |
Biological Process | regulation of nurse cell apoptotic process | |
Biological Process | triglyceride biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameO-acyltransferase
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila
Accessions
- Primary accessionA0A0Q9XGI6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 138-164 | Helical | ||||
Sequence: LFSWSSGFTNFTGLVNWGFLLLCIGGL | ||||||
Transmembrane | 198-215 | Helical | ||||
Sequence: ALFLVLYSFVHISLCLAV | ||||||
Transmembrane | 227-248 | Helical | ||||
Sequence: GLGMVIQIANIIFSVLLPVVII | ||||||
Transmembrane | 254-275 | Helical | ||||
Sequence: AFSIMGATSVCFYYSVLFLKLW | ||||||
Transmembrane | 364-383 | Helical | ||||
Sequence: LLEVLIGVNVLMALFQQWII | ||||||
Transmembrane | 414-438 | Helical | ||||
Sequence: LVWLIFFYLLFHSFLNAIGEVLYFA | ||||||
Transmembrane | 485-502 | Helical | ||||
Sequence: ASTIVFLFSAFFHEYLVS | ||||||
Transmembrane | 508-528 | Helical | ||||
Sequence: YKIWAFLGMMGQIPLSAISRY | ||||||
Transmembrane | 540-558 | Helical | ||||
Sequence: IIVWASIILGQPLCIMAYY |
Keywords
- Cellular component
Interaction
Subunit
Homodimer or homotetramer; both forms have similar enzymatic activities.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 13-43 | Disordered | ||||
Sequence: ARAMTATKDPKDQVPKTTTQPAQKNGAAGGL | ||||||
Compositional bias | 23-37 | Polar residues | ||||
Sequence: KDQVPKTTTQPAQKN | ||||||
Region | 87-127 | Disordered | ||||
Sequence: LDKDENGNGTSEKKLRYRRTQSVTRAEEISNKEAKLRKAQP |
Sequence similarities
Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length576
- Mass (Da)66,739
- Last updated2016-01-20 v1
- Checksum36E6CD87610B60A8
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0Q9X3X5 | A0A0Q9X3X5_DROMO | Dmoj\GI14192 | 583 | ||
B4KJR3 | B4KJR3_DROMO | Dmoj\GI14192 | 561 | ||
A0A0Q9XBA3 | A0A0Q9XBA3_DROMO | Dmoj\GI14192 | 373 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 23-37 | Polar residues | ||||
Sequence: KDQVPKTTTQPAQKN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH933807 EMBL· GenBank· DDBJ | KRG02728.1 EMBL· GenBank· DDBJ | Genomic DNA |