A0A0Q8YVG6 · A0A0Q8YVG6_9ACTN

Function

function

Catalyzes the NAD+-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD+ or NADP+, forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2.
Antibiotic biosynthesis.
Metabolic intermediate biosynthesis; 2-deoxystreptamine biosynthesis; 2-deoxystreptamine from D-glucose 6-phosphate: step 3/4.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site38Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site40Charge relay system
Active site43Charge relay system
Binding site63Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site64Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site93Zn2+ 2 (UniProtKB | ChEBI)
Binding site96Zn2+ 2 (UniProtKB | ChEBI)
Binding site99Zn2+ 2 (UniProtKB | ChEBI)
Binding site107Zn2+ 2 (UniProtKB | ChEBI)
Site148Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Binding site175NAD+ (UniProtKB | ChEBI)
Binding site195NAD+ (UniProtKB | ChEBI)
Binding site200NAD+ (UniProtKB | ChEBI)
Binding site262-264NAD+ (UniProtKB | ChEBI)
Binding site286-287NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionL-threonine 3-dehydrogenase activity
Molecular Functionzinc ion binding
Biological ProcessL-threonine catabolic process to glycine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-threonine 3-dehydrogenase
  • EC number
  • Short names
    TDH

Gene names

    • Name
      tdh
    • ORF names
      ASE41_37995

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Root264
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A0Q8YVG6

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain25-133Alcohol dehydrogenase-like N-terminal
Domain174-300Alcohol dehydrogenase-like C-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    342
  • Mass (Da)
    36,566
  • Last updated
    2016-01-20 v1
  • Checksum
    1B05D29FD9898FF2
MKALVKEKAEPGLWLRDVPEPVVGHGDVLIKVLRTGICGTDLHIRSWDGWAQQTISTPLVLGHEFVGEVVGTGRDVTDIAVGDRVSGEGHLVCGRCRNCLAGRRHLCRATVGLGVGRDGAFAEYVALPASNVWVHRVPVDLDVAAIFDPFGNAVHTALSFPLVGEDVLITGAGPIGLMAAAVARHAGARNVMITDVSEERLELARKIGASLALNVSRASIADGQRELGLREGFDIGLEMSGRPEAMRDMIANMTHGGRIAMLGLPAEEFPVDWARIVTSMITVKGIYGREMFETWYAMSVLLEGGLDLAPVITGRYGHRDFEAAFADAASGRGGKVILDWTA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LMIZ01000060
EMBL· GenBank· DDBJ
KRC98168.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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