A0A0Q8MLP6 · A0A0Q8MLP6_9HYPH

  • Protein
    Probable cytosol aminopeptidase
  • Gene
    pepA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
    EC:3.4.11.1 (UniProtKB | ENZYME | Rhea)
  • Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
    EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site265Mn2+ 2 (UniProtKB | ChEBI)
Binding site270Mn2+ 2 (UniProtKB | ChEBI)
Binding site270Mn2+ 1 (UniProtKB | ChEBI)
Active site277
Binding site288Mn2+ 2 (UniProtKB | ChEBI)
Binding site347Mn2+ 1 (UniProtKB | ChEBI)
Binding site349Mn2+ 2 (UniProtKB | ChEBI)
Binding site349Mn2+ 1 (UniProtKB | ChEBI)
Active site351

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cytosol aminopeptidase
  • EC number
  • Alternative names
    • Leucine aminopeptidase
      (LAP
      ) (EC:3.4.11.10
      ) . EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)
    • Leucyl aminopeptidase

Gene names

    • Name
      pepA
    • ORF names
      ASE04_17295

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Root708
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Rhizobium/Agrobacterium group > Rhizobium

Accessions

  • Primary accession
    A0A0Q8MLP6

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain345-352Cytosol aminopeptidase

Sequence similarities

Belongs to the peptidase M17 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    499
  • Mass (Da)
    52,470
  • Last updated
    2016-01-20 v1
  • Checksum
    78E5D9CC310F049B
MSAKFEISFEKTAEPTGGYAILLKASEAETAAGAKVVDPASVIARASNVAGFSAKLATALDIVAPEGSPTERIFVIGLGKPGSLTTHDWLKVGGASASKIKNASSVTIFLDAPDVEVGAQQAADFALGMLLRAYSFDTYKTKKADEETAGKNRGEPTKVVIVTAAASEAAEIFKISLAVAGGVNLARDLVNEPPNVLGPVEFAAKAKELEALGVEVEILTEQEMRKLGMGALLGVAQGSVRPPRLAVMQWKGGKSGEQPVAFIGKGVVFDTGGISIKPAAGMEDMKGDMGGAAAVTGLMHVLAARKAPANVVGIIGLVENMPDGNAQRPGDIVTSMSGQTIEVINTDAEGRLVLCDALWYCNDRFKPKFMINLATLTGAILVALGNVHAGLFSNDDELSEQLTAAGLVTREKLWRMPMGKEYDKMIDSKFADMKNTGGRHAGSITAAHFLKRFVQDTPWAHLDIAGTAMGSPLDEINQSWGSGFGVRLLDELVRAHYES

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LMHV01000043
EMBL· GenBank· DDBJ
KRB50306.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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