A0A0Q7B4A9 · A0A0Q7B4A9_9ACTN

  • Protein
    Phosphoenolpyruvate carboxykinase [GTP]
  • Gene
    pckG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site74substrate
Binding site211-213substrate
Binding site264substrate
Binding site265-270GTP (UniProtKB | ChEBI)
Active site266
Binding site391-393substrate
Binding site393GTP (UniProtKB | ChEBI)
Binding site424GTP (UniProtKB | ChEBI)
Binding site517-520GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      ASC77_13310

Organism names

  • Taxonomic identifier
  • Strain
    • Root1257
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Propionibacteriales > Nocardioidaceae > Nocardioides

Accessions

  • Primary accession
    A0A0Q7B4A9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-232Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain237-602Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    610
  • Mass (Da)
    67,497
  • Last updated
    2016-01-20 v1
  • Checksum
    C7C99715E4B5D564
MVDVNSALDEAGLTNPRVREYVAHWAAITRPDRVEVVSAADDARLLQEAVDAGELLPAGEGRYYSRSYHKDTARSEERTVVATSKEDDRGVYNNWKPAAEMTELLTERMTGASAGKTMYVIPYLMAPPGSPLEAYAAGVELTDSRPVVLHMIRMSRVAASYVNDLEDPDSFVRAVHVTGDLENLGQGTPDDQRYFATVADERTILHFGSSYGGNALLGKIAHGLRQACYDGRASGVFLAEQFMLLGITDKETGQRWHICGGFPSASGKTNLAMTLAPDALGDRYHVEFYGDDIAWLWVGDDGRVYGMNPEFGVFGVAKDTNEKTNPGALESIREGTGVIFTNVAYNPRTQEVWWEGMTKNPPEDVTDWQDWKGELISERAADDTSPWAHPNSRFTTTLANVPNVAGDFQAPAGVPIDAIIFGGRTSDREPLVRAITDLAEGVYDGLTLGAEATFAAEGVDGQLRYDPMSMRPFMAYGEGDYAAHWLKIIGSATEQPIFAHVNWFQRGDDGHFRWPGYRDNLRALLWLVRFKDGDVKGRQTPVGVLPTVEELELEGVEITPEDLEIVLSIDNERWRQEMGFREAHLKGFDRVPEEIWEAHRRVAAALDAEA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LMDV01000009
EMBL· GenBank· DDBJ
KQW47436.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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