A0A0Q5WLH2 · A0A0Q5WLH2_9HYPH

  • Protein
    Fumarate hydratase class II
  • Gene
    fumC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site98-100substrate
Binding site129-132substrate; in site B
Binding site139-141substrate
Binding site187substrate
Active site188Proton donor/acceptor
Active site318
Binding site319substrate
Binding site324-326substrate
Site331Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processmalate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC
    • ORF names
      ASG58_15790

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Leaf383
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Rhizobiaceae > Rhizobium/Agrobacterium group > Rhizobium

Accessions

  • Primary accession
    A0A0Q5WLH2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-342Fumarate lyase N-terminal
Domain408-460Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    463
  • Mass (Da)
    49,222
  • Last updated
    2016-01-20 v1
  • Checksum
    170A3611D63E4951
MTATRTETDTFGPIEVENDRYWGAQAQRSLGNFKIGWEKQPLSIVRALGIVKQAAARANMALGRLDPAVGEPIIRAAQEVIDGKLNEHFPLVVWQTGSGTQSNMNANEVISNRAIELLGGVMGSKKPVHPNDHVNMSQSSNDTFPTAMHIACAERVVHDLLPALKHLHAALDAKVKAFDHIIKIGRTHTQDATPLTLGQEFSGYAAQVASSIKRIEMTLPGLQELAQGGTAVGTGLNAPIGFAEKVAEEIASITGIAFTSAPNKFEALAAHDSMVFSHGAINATAAALFKIANDIRLLGSGPRSGLGELSLPENEPGSSIMPGKVNPTQCEALTQVCVQVFGNHASLTFAGSQGHFELNVYNPLMAYNFLQSVQLLADAAISFTDNCVTGIEAREDNIKAALDRSLMLVTALAPKIGYDNAAKIAKTAHKNGTTLREEAVGGGYVTNEEFDAVVRPETMISPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LMQD01000029
EMBL· GenBank· DDBJ
KQS74439.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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