A0A0Q4Y6R8 · A0A0Q4Y6R8_9BURK

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.
    EC:6.5.1.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site7Mg2+ 1 (UniProtKB | ChEBI)
Binding site34Mg2+ 1 (UniProtKB | ChEBI)
Active site106
Active site147Proton donor/acceptor
Binding site147Mg2+ 1 (UniProtKB | ChEBI)
Binding site149Mg2+ 1 (UniProtKB | ChEBI)
Site149Transition state stabilizer
Site218Important for catalytic activity
Binding site245Mg2+ 1 (UniProtKB | ChEBI)
Active site246Proton acceptor
Binding site246Mg2+ 1 (UniProtKB | ChEBI)
Site246Interaction with DNA substrate

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA ligase (ATP) activity
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Biological ProcessDNA recombination
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA ligase (ATP)
  • EC number
  • Alternative names
    • NHEJ DNA polymerase

Gene names

    • ORF names
      ASF43_14270

Organism names

Accessions

  • Primary accession
    A0A0Q4Y6R8

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region257-280Disordered
Domain605-747ATP-dependent DNA ligase family profile
Region825-844Disordered

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,133
  • Mass (Da)
    125,098
  • Last updated
    2016-01-20 v1
  • MD5 Checksum
    70E005E0B79D6F8175056F20D9E94C4C
MRVATWNINNVVKRLDRLLDWLERTQPDVVALQELKTPTAQFPAEALREAGYQSVVAGQRAWNGVALLSRGHEPVPVITALPGDPKDKEARYIEAAIHGVLYACLYLPNGNPQPGPKFDYKLRWFERMRVRAAELWASGNPVVLAGDWNVVPTDADIYKPDTWRDNALLQPEPREAYAAILAQGWTDALAHTHPQAQQFTFWDYRRKRWERNAGLRIDHILVSKPLALIDAGVDRDERAHDNASDHAPVWAEIQPAKTPRKRPAASARRSSIAAPAGVAPAVQSSDAPLSRYNAKRNFSKTAEPAGVVAAKRAAKGAASAGPLQFVIQKHWASRLHYDFRLELDGVMLSWAVPKGPSYDPAVQQMAIHVEDHPVSYNTFEGTIPKKEYGGGTVLIWDRGTWEPVGNPREGLANGKILFKLHGQKLAGLWELVRISKPGQKKQDQWLLFKKRGDAWARPSTEYDVITALPDSVVDRPLGLIEDREPREAARPRRAVPTATAALLEGAVKAPLPAKLAPQLATLVSSVPPGDWIIETKFDGYRLLARIDRGGVRLFTRNGHDWTAKLQPLADAVGTLGLDRAWLDTEIVVLNDAGVPDFNRLQNAIDNARTADIVMFAFDLPFSGGMDLRAVPLANRRALLQQIFSARDNELVRFSQSFDALPATLLSAACQMGLEGVMVKRADAPYASGRTEAWMKLKCQHRQEFVVVGFTNRSGNAKEVGGLLLGYHEDGAFRFAGSVGTGWGASTGRQLHDLLTKIEVATPAVDPTDTKPGRWSKRAAGTERWVKPVTVVEVAFAEWTPDRRVRHAVFRGIRTDKPAGHIVRERAKTSQGAAPARSIPAKTATSTVKISHPERVIDPSTGLRKIDLVRYYGSIAEWMLPHLKNRPASLVRAPTGITGELFYQKHPDTKMPGMQELDAALWPGHAALLAVDSAESLVMAAQMNVVEFHTWNSVAKRIDQPDRFILDLDPGDGVTWPMLQEAAILTRALLTELGLESWLKTSGGKGLHVVVPLTPRLDYTAVKAFSQAVVRHMAKVIPSKFVAVMGGSNRIGKIFIDYLRNGHGQTTACAFSARSRPGLGVSMPVAWEQLPELKGGAQWTIATAREYLSFQQEDPWRGYWKKRQSLGAAIRLLN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LMMV01000021
EMBL· GenBank· DDBJ
KQP15185.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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