A0A0P9KTC1 · A0A0P9KTC1_9PSED

Function

function

Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site206-207ATP (UniProtKB | ChEBI)
Binding site288ATP (UniProtKB | ChEBI)
Binding site310ATP (UniProtKB | ChEBI)
Binding site319ATP (UniProtKB | ChEBI)
Active site478Cysteine persulfide intermediate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionCCA tRNA nucleotidyltransferase activity
Molecular FunctiontRNA binding
Molecular FunctiontRNA-uracil-4 sulfurtransferase activity
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process
Biological Processthiazole biosynthetic process
Biological ProcesstRNA 4-thiouridine biosynthesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA sulfurtransferase
  • EC number
  • Alternative names
    • Sulfur carrier protein ThiS sulfurtransferase
    • Thiamine biosynthesis protein ThiI
    • tRNA 4-thiouridine synthase

Gene names

    • Name
      thiI
    • ORF names
      ALO88_01157

Organism names

Accessions

  • Primary accession
    A0A0P9KTC1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain84-188THUMP
Domain426-502Rhodanese

Sequence similarities

Belongs to the ThiI family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    505
  • Mass (Da)
    56,709
  • Last updated
    2016-01-20 v1
  • MD5 Checksum
    B30E2230DBFF467717ACDE247D6ED1B0
MSNFRYNPRPPFSVGTSRSVSMKLIVKVFPEITIKSPPVRKKFIRQLGKNIRTVLRELDADIVVGGVWDNLEVETRLTDPKVLQGIRDRLSCMPGIANFLQVAEYPLGDMDDVVAKCKLHYADLLPGTMFSVRCKRAGRHDFSSMDVEKYVGSQLRMQCGAAGIELKKPDLVVRMEIRDQRLFVVHDQHKGMGGYPLGALEQTLVLMSGGFDSTVAAYQIMRRGLMAHFCFFNLGGRAHELGVMEVAHFIWKKYGSSQRVLFVSVPFEEVLGEILQKVDNSHMGVVLKRMMLRAASAVADRLEIDVLVTGEAISQVASQTLPNLSLIDAATDKLVLRPLVATHKQDIVDLATEIGTADFARHMPEYCGVISVNPKTNAKRNRVEYEEQQFDMAILEQALERAKLVSIDRVIDDLSRNIDIEEVSQALAGQVIIDIRHPDAQEDQPLQVPGVEIQTLPFYALNSRFKALDDTRQYLLYCDKGVMSRLHAHHLLSEGHANVRVYRPS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LJPT01000175
EMBL· GenBank· DDBJ
KPW43594.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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